Microsoft word - flyechin.doc
Echinacea is one of the top selling herbal
Echinacea is a member of the Asteraceae
if injected, but orally administered preparations
products in the US with sales worth more $US300
[Compositae] family, which includes sunflowers,
are not so likely to function. Clinical trials are
million dollars annually. A member of the daisy
daisies and the potent allergen, ragweed. Three
hampered by the fact that many of these
family, it is claimed to treat abscesses, burns,
species are used medicinally—E. angustifolia, E.
products lack appropriate quality control and
eczema, liver cancer, urinary tract infections,
pallida and E. purpurea, the latter being the most
cannot be standardised because the active
varicose leg ulcers, boils, and gingivitis, but mostly
commonly used in New Zealand. These
ingredient(s) has not been defined.
it is used to treat upper respiratory infections.
‘coneflowers' are perennial herbs, and productioninvolves drying the roots or juicing the stems,
In a recent study of 40 healthy male volunteers
flowers and roots, or ethanolic extraction of
who were administered the freshly expressed
sold as capsules, pills, tinctures, teas, creams
various compounds. The method of manufacture,
juice of E. purpurea or placebo, echinacea did not
for topical use, and toothpaste, or in
the time of harvest and the part of the plant
enhance the immune system as measured by the
combination with other compounds
harvested are all variables that need to be taken
phagocytic activity of white blood cells and the
marketed to children as fizzy tablets also
into account when attributing clinical efficacy to
production of cytokines. Researchers were
containing vitamin C
echinacea. The root is said to contain the highest
surprised to find that echinacea decreased the
purported to support and promote the natural
levels of active components and the stem to be
levels of serum ferritin, as that had not been
powers of resistance of the body, especially in
less desirable. Claimed potency is said to depend
predicted. They concluded that the ‘immune
infections of the nose and throat
on how long the herb is stored before use and how
stimulation' does not result from oral intake.
unproven in many clinical trials to prevent or
finely it is powdered and processed.
ameliorate the symptoms of upper respiratory
Pharmacies and health food shops in Wellington
Studies show that there are indeed many
were found to recommend echinacea most
unproven in its claimed immune-enhancing
potentially pharmacologically active compounds in
commonly as a treatment for a patient presenting
echinacea, but whether there is sufficient present
with obvious symptoms of asthma following a chest
a known cause of asthma and anaphylaxis in
in crude extracts to be effective is debatable.
allergic patients
Echinacoside is claimed to be a natural antibiotic
Lack of efficacy in preventing upper
comparable to penicillin, but its concentration is
respiratory infection was reported in a trial of
Echinacea was used by American Indians to
not likely to be sufficient to have any significant
302 volunteers in Germany. They received oral
treat snake bite and relieve fever, and was
effect. Polysaccharides, such as heteroxylan and
ethanolic extracts of echinacea roots, or placebo,
incorporated into a 19th century wonder cure
arabinoglycan, are touted as having major
for 12 weeks. The number of volunteers who
called Meyer's Blood Purifier. With the advent of
pharmacologic effects on the immune system,
became infected and the length of time until they
sulfa antibiotics, echinacea lost its popularity as
though these are likely to be digestively destroyed
became ill did not differ significantly between the
an anti-infective agent. Most recent research has
when taken orally. Echinacea has a pungent smell
two groups. Even if there is a relative risk
been carried out in Germany, where echinacea
and taste caused by echinacein, an isobutylamide
reduction attributable to taking echinacea, there
extracts are injected, a procedure not pursued in
that is responsible for a tingling sensation if fresh
are dangers in taking it for any length of time. The
the US or elsewhere.
stems are chewed. Echinacein is said to counteract
recommended treatment period is less than 8
the invasion of tissues by bacteria. This may be so
weeks because of the risk of liver poisoning. In
For more information: http://skeptics.org.nz
fact, people who use other hepatotoxic drugs,
Melchart D, Walther E, Linde K, Brandmaier R,
such as anabolic steroids, methotrexate or
Lersch C. Echinacea root extracts for upper
ketoconazole, are warned not to take echinacea.
respiratory infections. Arch Fam Med
Several other trials back up these results,
including one where 117 volunteers were treated
Mullins RJ, Heddle R. Adverse reactions
with echinacea and then challenged with a
associated with Echinacea: the Australian
rhinovirus. Similar numbers of people caught colds
experience. Ann Allergy Asthma Immunol
whether they took echinacea or placebo and the
severity of symptoms did not differ.
Echinacea – RxList Herbal FAQ.
A 2002 Australian study of adverse drug
Schwartz E, Metzler J, Diedrich JP,
reactions found that 51 cases including examples
Freudenstein J, Bode C, Bode JC. Oral stimulation
of anaphylaxis, acute asthma and skin rashes were
of freshly expressed juice of Echinacea purpurea
As with many herbs, it's unsettled whether
attributable to echinacea ingestion. Several
herbs fail to stimulate the non-specific immune
echinacea is useful. Also, many herbal
patients required hospitalisation. Americans with
response in healthy young men: results of a
products are not standardized as to what's in
known sensitivity to ragweed are warned not to
double-blind, placebo-controlled crossover study.
them, so even if something is useful, you can't
take echinacea. Patients with immune diseases,
J Immunother 2002;25(5):413-20
be sure that the quality control or dosage
such as lupus, multiple sclerosis or AIDs are likely
Turner RB, Riker DK, Gangemi JD. Ineffectiveness
that makes it useful is in the bottle. The FDA
to suffer adverse reactions to echinacea, though
of Echinacea for prevention of
doesn't regulate that.
there are no warnings on containers available in
experimental rhinovirus colds. Antimicrob
supermarkets, pharmacies and health food shops.
Agents Chemother 2002;44(6):1708-9
Some dietary supplements do not contain
the ingredients or the amount of theingredients declared on the label. Forexample, in laboratory testing of 25 separate
Echinacea products, only 14 (56 percent) were
Douglas J. Echinacea-the purple coneflowers.
found to have the amount and type of
Echinacea and polyphenol (or marker
compound) claimed on the label
Executive Summary Echinacea.
Dr Stevphen Barrrett quoting a 2001
product review from ConsumerLab.com
Healey B, Burgess C, Siebers R, Beasley R,
Weatherall M, Holt S. Do natural health food
Just because it is a herb or
stores require regulation? NZMJ 13 September
marketed as a ‘natural' product,
does not guarantee it is either
effective or safe.
Source: http://skeptics.nz/wp-content/uploads/flyers/NZSkepticsFlyerEchinacea.pdf
Progress in Neuro-Psychopharmacology & Biological Psychiatry 31 (2007) 848 – 857 Effects of haloperidol and its pyridinium metabolite on plasma membrane permeability and fluidity in the rat brain Tetsuhito Murata a,⁎, Nobuyuki Maruoka a,b, Naoto Omata a, Yasuhiro Takashima a, Kazuo Igarashi c, Fumiyo Kasuya d, Yasuhisa Fujibayashi b, Yuji Wada a a Department of Neuropsychiatry, University of Fukui, Fukui 910-1193, Japan
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