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Journal of Cardiac Failure Vol. 14 No. 6 2008 Pioglitazone and Heart Failure: Results From a Controlled Study in Patients With Type 2 Diabetes Mellitus and Systolic Dysfunction THOMAS D. GILES, ALAN B. MILLER, MD,URI ELKAYAM, MONDIRA BHATTACHARYA, MD,AND ALFONSO PEREZ, New Orleans, Louisiana; Jacksonville, Florida; Los Angeles, California; Deerfield, Illinois Background: Thiazolidinediones are associated with fluid retention, often interpreted as worsening car-diac function, limiting their use in patients with heart failure (HF). We compared the effects of pioglita-zone and glyburide on cardiac function in patients with type 2 diabetes, systolic dysfunction, and NewYork Heart Association (NYHA) functional Class II/III HF.Methods and Results: Participants received pioglitazone or glyburide (6insulin) for 6 months in thisdouble-blind, randomized, multicenter study. The primary end point was time to HF, a composite ofcardiovascular mortality and hospitalization or emergency room (ER) visit for HF. Secondary endpointsincluded echocardiographic and functional classification assessments. An earlier time to onset and higherincidence of the primary endpoint was noted with pioglitazone (13%) versus glyburide (8%) (P 5 .024).Hospitalization or ER visit occurred in 30 pioglitazone and 15 glyburide participants, 19 and 12 of whom,respectively, continued treatment. Cardiac mortality (5 versus 6 participants, respectively) and cardiacfunction, as measured by change in ventricular mass index (P 5 .959), ejection fraction (P 5 .413), orfractional shortening (P 5 .280), were similar between treatments.Conclusions: Pioglitazone was associated with a higher incidence of hospitalization for HF without anincrease in cardiovascular mortality or worsening cardiac function (by echocardiography). (J CardiacFail 2008;14:445e452)Key Words: Cardiovascular disease, thiazolidinediones, left ventricular dysfunction.


Première Edition des Rencontres Africaines pour le Développement de la Petite Enfance au niveau Actes de la Conférence Cotonou-Bénin, 27 novembre 2012 Introduction La Première Edition des Rencontres Africaines pour le Développement de la Petite Enfance a été organisée au Bénin du 26 au 30 novembre 2012 autour du Thème « Développement Communautaire et Petite Enfance » Les rencontres ont été le fruit d'un partenariat dynamique entre le Gouvernement du Bénin, le Groupe de Travail de l'ADEA pour le développement de la petite enfance (GTDPE), l'Organisation des Nations Unies pour l'Education, la science et la culture (UNESCO) et le Réseau pour l'Education Pour Tous en Afrique (REPTA) en partenariat avec le Groupement des Retraités pour l'Education sans Frontières (GREF) et les Centres d'Entrainement aux Méthodes Actives (CEMEA). Elles ont été cofinancées par l'AFD, l'ADEA, l'UNESCO et le REPTA. Elles sont le couronnement de six mois de préparatifs menés avec les cellules nationales du REPTA, les équipes pays GREF et CEMEA, les réseaux nationaux DPE membres du GTDPE de l'ADEA dans les pays de les pays francophones de l'Afrique de l'Ouest et du Centre. Les rencontres avaient pour thème « Comment valoriser la contribution des organisations communautaires de base ». Ce thème a été abordé au travers de quatre sous thèmes que sont :

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in the treatment ofendometriosis Nicolo Bizzarri, Valentino Remorgida, Umberto Leone Roberti Maggiore, Carolina Scala, Emanuela Tafi, Valentina Ghirardi, Stefano Salvatore,Massimo Candiani, Pier Luigi Venturini & Simone Ferrero† †University of Genoa, IRCCS San Martino Hospital and National Institute for Cancer Research, Pharmacokinetic of DNG Department of Obstetrics and Gynaecology, Genoa, Italy

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cleaning Acceptance Limits for ApIs This article Cleaning Validation for the 21st discusses how to establish true science-based Century: Acceptance Limits for Active limits using data from clinical and Pharmaceutical Ingredients (APIs): toxicological studies, a risk-

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WALTER HALLSTEIN-INSTITUT FÜR EUROPÄISCHES VERFASSUNGSRECHT HUMBOLDT-UNIVERSITÄT ZU BERLIN WHI – Materials 2/03 RALF KANITZ/PHILIPP STEINBERG (HRSG.) NEUE RECHTSPRECHUNG DER EUROPÄISCHEN GERICHTE (EUGH, EUG) EXAMENSRELEVANTE ENTSCHEIDUNGEN KOMPAKT DARGESTELLT, KOMMENTIERT UND RECHTLICH EINGEORDNET Ralf Kanitz/Philipp Steinberg (Hrsg.), Neue Rechtsprechung der Europäischen Gerichte (EuGH, EuG). Examensrelevante Entscheidungen kompakt, Berlin, April 2003 Kontakt: Walter Hallstein-Institut für europäisches Verfassungsrecht Juristische Fakultät Humboldt-Universität zu Berlin Unter den Linden 6 D 10099 Berlin Tel.: ++49 (0) 30 2093 3440 Fax: ++49 (0) 30 2093 3449 www.whi-berlin.de Email: [email protected] und [email protected]


These e-Updates are a regular weekly item from K-State Extension Agronomy and SteveWatson, Agronomy e-Update Editor. All of the Research and Extension faculty in Agronomywill be involved as sources from time to time. If you have any questions or suggestions fortopics you'd like to have us address in this weekly update, contact Steve Watson,785-532-7105 [email protected], Jim Shroyer, Crop Production Specialist [email protected], or Curtis Thompson, Extension Agronomy State Leader and WeedManagement Specialist 785-532-3444 [email protected].


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Tim Guimond, MD, FRCPC, MSc, PhD (cand) Clinician-Investigator, Mental Health Service St. Michael's Hospital Lecturer, Department of Psychiatry University of Toronto • Science about the drug• Musings about the community reaction• Clinical issues: – Psychosis– Intertwining with sex– Harm reduction strategies– Treatment Structure of dopamine Structures of amphetamines


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Int. J. Biomedical Engineering and Technology, Vol. 1, No. 4, 2008 Dynamic generation of a Health Topics Overview from consumer health information documents Trudi Miller* and Gondy Leroy School of Information Systems and Technology, Claremont Graduate University, 130 E. Ninth Street, Claremont, CA 91711, USA E-mail: [email protected] E-mail: [email protected]


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