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Doi:10.1016/j.cardfail.2008.02.007

Journal of Cardiac Failure Vol. 14 No. 6 2008 Pioglitazone and Heart Failure: Results From a Controlled Study in Patients With Type 2 Diabetes Mellitus and Systolic Dysfunction THOMAS D. GILES, ALAN B. MILLER, MD,URI ELKAYAM, MONDIRA BHATTACHARYA, MD,AND ALFONSO PEREZ, New Orleans, Louisiana; Jacksonville, Florida; Los Angeles, California; Deerfield, Illinois Background: Thiazolidinediones are associated with fluid retention, often interpreted as worsening car-diac function, limiting their use in patients with heart failure (HF). We compared the effects of pioglita-zone and glyburide on cardiac function in patients with type 2 diabetes, systolic dysfunction, and NewYork Heart Association (NYHA) functional Class II/III HF.Methods and Results: Participants received pioglitazone or glyburide (6insulin) for 6 months in thisdouble-blind, randomized, multicenter study. The primary end point was time to HF, a composite ofcardiovascular mortality and hospitalization or emergency room (ER) visit for HF. Secondary endpointsincluded echocardiographic and functional classification assessments. An earlier time to onset and higherincidence of the primary endpoint was noted with pioglitazone (13%) versus glyburide (8%) (P 5 .024).Hospitalization or ER visit occurred in 30 pioglitazone and 15 glyburide participants, 19 and 12 of whom,respectively, continued treatment. Cardiac mortality (5 versus 6 participants, respectively) and cardiacfunction, as measured by change in ventricular mass index (P 5 .959), ejection fraction (P 5 .413), orfractional shortening (P 5 .280), were similar between treatments.Conclusions: Pioglitazone was associated with a higher incidence of hospitalization for HF without anincrease in cardiovascular mortality or worsening cardiac function (by echocardiography). (J CardiacFail 2008;14:445e452)Key Words: Cardiovascular disease, thiazolidinediones, left ventricular dysfunction.

web-edu.tv

Première Edition des Rencontres Africaines pour le Développement de la Petite Enfance au niveau Actes de la Conférence Cotonou-Bénin, 27 novembre 2012 Introduction La Première Edition des Rencontres Africaines pour le Développement de la Petite Enfance a été organisée au Bénin du 26 au 30 novembre 2012 autour du Thème « Développement Communautaire et Petite Enfance » Les rencontres ont été le fruit d'un partenariat dynamique entre le Gouvernement du Bénin, le Groupe de Travail de l'ADEA pour le développement de la petite enfance (GTDPE), l'Organisation des Nations Unies pour l'Education, la science et la culture (UNESCO) et le Réseau pour l'Education Pour Tous en Afrique (REPTA) en partenariat avec le Groupement des Retraités pour l'Education sans Frontières (GREF) et les Centres d'Entrainement aux Méthodes Actives (CEMEA). Elles ont été cofinancées par l'AFD, l'ADEA, l'UNESCO et le REPTA. Elles sont le couronnement de six mois de préparatifs menés avec les cellules nationales du REPTA, les équipes pays GREF et CEMEA, les réseaux nationaux DPE membres du GTDPE de l'ADEA dans les pays de les pays francophones de l'Afrique de l'Ouest et du Centre. Les rencontres avaient pour thème « Comment valoriser la contribution des organisations communautaires de base ». Ce thème a été abordé au travers de quatre sous thèmes que sont :

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in the treatment ofendometriosis Nicolo Bizzarri, Valentino Remorgida, Umberto Leone Roberti Maggiore, Carolina Scala, Emanuela Tafi, Valentina Ghirardi, Stefano Salvatore,Massimo Candiani, Pier Luigi Venturini & Simone Ferrero† †University of Genoa, IRCCS San Martino Hospital and National Institute for Cancer Research, Pharmacokinetic of DNG Department of Obstetrics and Gynaecology, Genoa, Italy

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The World Journal of Biological Psychiatry, 2008; 9(1): 623 World Federation of Societies of Biological Psychiatry (WFSBP)Guidelines for Biological Treatment of Substance Use and RelatedDisorders, Part 1: Alcoholism MICHAEL SOYKA1, HENRY R. KRANZLER2, MATS BERGLUND3, DAVID GORELICK4,VICTOR HESSELBROCK2, BANKOLE A. JOHNSON5, HANS-JU THE WFSBP TASK FORCE ON TREATMENT GUIDELINES FOR SUBSTANCE USEDISORDERS*

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British Journal of Pharmacology (2001) 132, 879 ± 888 ã 2001 Nature Publishing Group All rights reserved 0007 ± 1188/01 $15.00 A1 adenosine receptors inhibit multiple voltage-gated Ca2+ channel subtypes in acutely isolated rat basolateral amygdala neurons*,1Brian A. McCool & 1Je€ery S. Farroni 1Department of Medical Pharmacology and Toxicology, The Texas A&M University System Health Science Center, College

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The Journal of Neuroscience, November 1, 1996, 16(21):6830 – 6838 Differential Regulation of NMDAR1 mRNA and Protein by Estradiolin the Rat Hippocampus Adam H. Gazzaley,1 Nancy G. Weiland,3 Bruce S. McEwen,3 and John H. Morrison1,2 1Laboratories for Neurobiology of Aging, F ishberg Research Center for Neurobiology, New York, New York 10029-6574,2Department of Geriatrics and Adult Development, The Mount Sinai School of Medicine, New York, New York 10029, and3Laboratory of Neuroendocrinology, Rockefeller University, New York, New York 10021

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JOURNAL OF TEACHING AND LEARNING, 2012, VOL. 8, NO. 2 Exemplary Teaching Practices Across Educational Contexts (P-20+): Unifying Principles and an Ecological Model for Teaching for All to Learn Judith Ableser Ph.D. Oakland University Abstract This paper highlights that teaching for all to learn is a central theme of exemplary practice across all educational contexts from preschool through graduate school (P-20+). Ten unifying principles will be presented based on this theme. Although these principles are consistent across P-20+ settings, the ways in which these practices are implemented will differ, depending on the context. An ecological model for teaching for all to learn will be developed, presenting a conceptual schema of the components and factors involved in exemplary teaching across all contexts from preschool, special education, elementary, secondary, through all levels of higher education.

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CÓDIGO DE MARKETING DE MARS, INC. PARA ALIMENTOS, CHOCOLATE, CONFITERÍA Objetivo, ámbito y plazos Mars, Inc. posee gran parte de las principales marcas de chocolate, confitería, chicle y alimentación en todo el mundo y cuenta con una dilatada trayectoria en la comercialización responsable de sus productos. Nuestro código de marketing, adoptado por primera vez en 2008, refleja nuestros valores y principios corporativos así como nuestro compromiso con campañas de marketing responsables dentro de un entorno de marketing dinámico. Este código pretende reafirmar nuestro compromiso con respecto al uso creativo y responsable de la publicidad en todas sus formas a la hora de comercializar nuestros productos. Además, pretende explicar el modo en que Mars utiliza técnicas de marketing específicas así como nuevos medios de comunicación acordes con nuestro compromiso de respetar la privacidad de nuestros consumidores. Este código se aplica a las campañas de marketing de todos los productos de alimentación, chocolate, confitería y chicle producidos y autorizados por Mars, Inc. y Wrigley a escala internacional. Así mismo se aplica a los materiales y actividades promocionales elaborados por Mars, Inc. que se citan a continuación: páginas web de marcas, comunidades online, publicidad en los medios de comunicación (por ejemplo emisiones de radio difusión, prensa escrita o digital), publirreportajes, patrocinio, campañas de prensa y promociones de las marcas. Queremos garantizar que los titulares de licencia y los socios comerciales cumplen nuestros elevados estándares de calidad. No obstante, Mars no asume ninguna responsabilidad por las acciones de terceros sin licencia en las que puedan verse envueltos nuestros productos y nuestras marcas. Los compromisos en este código se suman a todas las disposiciones legales o compromisos de autorregulación aplicables en cualquier país. A raíz de la reciente adquisición de Wrigley por parte de Mars, Inc., el código también se aplicará a los productos de Wrigley. En lo que respecta a los productos de Wrigley, a lo largo del año 2010 tendrá lugar la implantación del código en la mayor parte de los países y concluirá a finales de 2013 para todos los productos a escala mundial. Antes de dicha fecha se irán retirando, con la mayor celeridad posible, algunas iniciativas promocionales de la empresa así como ciertas actividades en marcha. Los planes reales de retirada dependerán de los compromisos contractuales existentes y de las existencias. El código de marketing de Mars es un documento en constante evolución y es probable que requiera revisiones periódicas al objeto de garantizar su coherencia con nuestros valores y principios corporativos así como con los cambios que se producen en el mercado y dentro de nuestra empresa. Nuestro código de marketing también incluye nuestras directrices de publicidad, cuya finalidad es servir de guía a la hora de decidir sobre el tiempo y los espacios de publicidad adquiridos a proveedores de contenidos en los medios de comunicación. El código de marketing de Mars es fundamentalmente para uso interno y su finalidad es ayudar a todos nuestros asociados (y, en especial, a aquellos involucrados en marketing,

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JOURNAL OF CLINICAL MICROBIOLOGY, Aug. 1995, p. 1979–1983 0095-1137/95/$04.0010Copyright 1995, American Society for Microbiology Diagnostic Difficulties Caused by a Nonclamped Schizophyllum commune Isolate in a Case of Fungus Ball of the Lung LYNNE SIGLER,1,2* LUIS M. DE LA MAZA,3 GRACE TAN,3 KEITH N. EGGER,4 AND RICHARD K. SHERBURNE2 University of Alberta Microfungus Collection and Herbarium, Devonian Botanic Garden,1 and Medical Microbiology &

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cleaning Acceptance Limits for ApIs This article Cleaning Validation for the 21st discusses how to establish true science-based Century: Acceptance Limits for Active limits using data from clinical and Pharmaceutical Ingredients (APIs): toxicological studies, a risk-

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Occurrence of Estrogenic Endocrine Disruptors in Groundwater Wisconsin State Laboratory of Hygiene Investigators: William Sonzogni PhD, Director Jocelyn Hemming, PhD, Assistant Scientist Miel Barman, Environmental Toxicologist Steve Geis, Chemist Supervisor July 1, 2004-June 30, 2006 This project was supported, in part, by General Purpose Revenue funds of the State of Wisconsin

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WALTER HALLSTEIN-INSTITUT FÜR EUROPÄISCHES VERFASSUNGSRECHT HUMBOLDT-UNIVERSITÄT ZU BERLIN WHI – Materials 2/03 RALF KANITZ/PHILIPP STEINBERG (HRSG.) NEUE RECHTSPRECHUNG DER EUROPÄISCHEN GERICHTE (EUGH, EUG) EXAMENSRELEVANTE ENTSCHEIDUNGEN KOMPAKT DARGESTELLT, KOMMENTIERT UND RECHTLICH EINGEORDNET Ralf Kanitz/Philipp Steinberg (Hrsg.), Neue Rechtsprechung der Europäischen Gerichte (EuGH, EuG). Examensrelevante Entscheidungen kompakt, Berlin, April 2003 Kontakt: Walter Hallstein-Institut für europäisches Verfassungsrecht Juristische Fakultät Humboldt-Universität zu Berlin Unter den Linden 6 D 10099 Berlin Tel.: ++49 (0) 30 2093 3440 Fax: ++49 (0) 30 2093 3449 www.whi-berlin.de Email: [email protected] und [email protected]

webapp.agron.ksu.edu

These e-Updates are a regular weekly item from K-State Extension Agronomy and SteveWatson, Agronomy e-Update Editor. All of the Research and Extension faculty in Agronomywill be involved as sources from time to time. If you have any questions or suggestions fortopics you'd like to have us address in this weekly update, contact Steve Watson,785-532-7105 [email protected], Jim Shroyer, Crop Production Specialist [email protected], or Curtis Thompson, Extension Agronomy State Leader and WeedManagement Specialist 785-532-3444 [email protected].

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saving faces changing lives® American Association of Oral and Maxillofacial Surgeons Medication-Related Osteonecrosis of the Jaw—2014 Update Special Committee on Medication- Related Osteonecrosis of the Jaws: The Special Committee recommends changing the Salvatore L. Ruggiero, DMD, MD, Clinical nomenclature of bisphosphonate-related osteonecrosis of

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www1.ece.neu.edu

Information Cut for Clustering using a Gradient Descent Approach Robert Jenssen∗ 1 , Deniz Erdogmus?, Kenneth E. Hild II†, Jose C. Principe‡ and Torbjørn Eltoft∗, ∗Department of Physics, University of Tromsø, N-9037 Tromsø, Norway ?Oregon Graduate Institute, OHSU, Portland OR. 97006, USA †Biomagnetic Imaging Lab, University of California, SF, CA. 94143, USA

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Tim Guimond, MD, FRCPC, MSc, PhD (cand) Clinician-Investigator, Mental Health Service St. Michael's Hospital Lecturer, Department of Psychiatry University of Toronto • Science about the drug• Musings about the community reaction• Clinical issues: – Psychosis– Intertwining with sex– Harm reduction strategies– Treatment Structure of dopamine Structures of amphetamines

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Where have all the antibiotic patents gone? Martin L Katz, Lisa V Mueller, Mark Polyakov & Steven F Weinstock Patent and regulatory hurdles combined with low returns on investment are stifling antibiotic R&Din the pharmaceutical industry. Since the discovery of penicillin by major pharma companies are still players in Of the companies examined, only eight

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Material Safety Data Sheet Hazard Alert Code Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION PRODUCT NAME STATEMENT OF HAZARDOUS NATURE CONSIDERED A HAZARDOUS SUBSTANCE ACCORDING TO OSHA 29 CFR 1910.1200. Company: Santa Cruz Biotechnology, Inc. Address:2145 Delaware Ave Santa Cruz, CA 95060

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Int. J. Biomedical Engineering and Technology, Vol. 1, No. 4, 2008 Dynamic generation of a Health Topics Overview from consumer health information documents Trudi Miller* and Gondy Leroy School of Information Systems and Technology, Claremont Graduate University, 130 E. Ninth Street, Claremont, CA 91711, USA E-mail: [email protected] E-mail: [email protected]

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IEEE TRANSACTIONS ON COMPUTER-AIDED DESIGN OF INTEGRATED CIRCUITS AND SYSTEMS, VOL. 28, NO. 7, JULY 2009 The Tire as an Intelligent Sensor Sinem Coleri Ergen, Member, IEEE, Alberto Sangiovanni-Vincentelli, Fellow, IEEE, Xuening Sun, Member, IEEE, Riccardo Tebano, Sayf Alalusi, Giorgio Audisio, and Marco Sabatini Abstract—Active safety systems are based upon the accurate