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Cleveland.edu

Research & Practice
State of the Art
Daniel Redwood, DC
Cleveland Chiropractic College–
Kansas City and Los Angeles
Carl S. Cleveland III, DC J. Michael Flynn, DC Cheryl Hawk, DC, PhD Anthony Rosner, PhD 2010 Cleveland Chiropractic College–Kansas City and Los Angeles All rights reserved.
Research & Practice
State of the Art
Since chiropractic's breakthrough decade in the 1970s—when the U.S. federal government included chiropractic services in Medicare and federal workers' compensation coverage, approved the Council on Chiropractic Education (CCE) as the accrediting body for chiropractic colleges, and sponsored a National Institutes of Health (NIH) conference on the research status of spinal manipulation—the profession has grown and matured into an essential part of the nation's healthcare system. Chiropractic was born in the United States in the late 19th century and the U.S. is home to approximately 65,000 of the world's 90,000 chiropractors.1 The chiropractic profession is the third largest independent health profession in the Western world, after medicine and dentistry. Doctors of chiropractic are licensed throughout the English-speaking world and in many other nations as primary contact providers, licensed for both diagnosis and treatment without medical referral. In 2005, the World Health Organization (WHO) published WHO Guidelines on Basic Training and Safety in Chiropractic, which documented the status of chiropractic education and practice worldwide and sought to ensure high standards in nations where chiropractic is in the early stages of development.2 Rigorous educational standards are supervised by government-recognized accrediting agencies in many nations, including CCE in the United States. After fulfilling college science prerequisites similar to those required to enter medical schools, chiropractic students must complete a chiropractic college program of four academic years, which includes a wide range of courses in anatomy, physiology, pathology, and diagnosis, as well as spinal adjusting, physiotherapy, rehabilitation, public health and nutrition.
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The NIH classifies chiropractic as a manipulation and body-based form of complementary and alternative medicine (CAM), although chiropractors, mindful of the major strides they have made toward mainstream status, often prefer to be known as "integrative" rather than CAM practitioners.3 Utilization rates for both chiropractic and CAM are substantial. Chiropractors in the United States see approximately 19 million individual patients per year. At least one third of U.S. adults routinely use CAM therapies, and Americans schedule hundreds of millions of office visits per year to licensed CAM professionals, at a cost of tens of billions of dollars.4 Chiropractic shares with other CAM professions a health philosophy that emphasizes the inherent recuperative and self-healing capacities of the body, with a worldview based on promoting balance of body and mind through natural methods of prevention and treatment. Chiropractic is the only profession identified as CAM whose services are covered by a substantial majority of health insurance policies. Research: Cornerstone of
In the years since the 1970s, research on the effectiveness of chiropractic care, particularly the manual methods described as spinal manipulation or adjustment (94% of which is delivered by chiropractors),5 has expanded considerably. There are now approximately 100 randomized clinical trials on spinal manipulation. Most of these involve investigations into its effects on back pain, neck pain, and headaches, but a growing number of projects address other areas of chiropractic practice, including extremity (leg and arm) problems and nonmusculoskeletal conditions such as infantile colic and hypertension. In a large majority of these studies, spinal manipulation outperformed comparison therapies or placebo. Significantly, not a single patient in any of these studies experienced a major adverse side-effect. To strengthen the chiropractic research community, the U.S. Health Resources and Services Administration funded for 12 years (1995–2006) an annual chiropractic Research Agenda Conference (RAC), where ChiroprACtiC reSeArCh And prACtiCe
researchers and practitioners met to hear reports on completed studies, propose and implement new research projects, develop strategies for interdisciplinary collaboration, and advance the overall direction of chiropractic research. After the completion of this seed funding from the federal government, the profession has self-funded continued annual RAC meetings in conjunction with the annual meeting of the Association of Chiropractic Colleges. The resulting upsurge in chiropractic research has been dramatic. As Scott Haldeman, DC, MD, PhD, who presided over the World Health Organization's Bone and Joint Decade 2000–2010 Task Force on Neck Pain and Its Associated Disorders, wrote in 2010, "There was a time, not long ago, when there was little or no evidence to support the practice of manipulation that is the mainstay of chiropractic practice … There has, however, been a rapid growth in the number of clinical trials that have studied the effectiveness of manipulation, mobilization and massage over the past 20 years and … there is now little dispute amongst knowledge-able scientists that manipulation is of value in the management of back pain, neck pain and headaches that make up 90% or more of all patients who seek chiropractic care."6 Most of the research cited below focuses on the effectiveness of manual adjustment (manipulation) of the spine and other musculoskeletal structures. While this is the chiropractor's primary area of specialty, the care delivered by chiropractors includes much more, reflecting chiroprac-tors' expertise in diagnosis, radiology, rehabilitation, physiotherapy, non-manipulation manual methods (mobilization and massage), nutrition, prevention, and health promotion, along with their widely acknowledged skills in doctor-patient relationships.7, 8 In a 1998 Archives of Internal Medicine article, Harvard Medical School professors Kaptchuk and Eisenberg described these relationships appreciatively: "Chiropractic's ultimate lesson may be to reinforce the principle that the patient-physi-cian relationship is fundamentally about words and deeds of connection and compassion. Chiropractic has managed to embody this message in the gift of the hands."8 StAte of the Art
Patient satisfaction with chiropractic care is based on many factors, foremost among these the judgment by patients that their therapeutic goals—particularly relief of pain and restoration of function—have been met or exceeded. In 2010, the Secretary of Health and Human Services, Kathleen Sebelius, submitted a Report to Congress on the Demonstration of Coverage of Chiropractic Services Under Medicare.9 This report noted that, "Sixty percent of respondents indicated that they received ‘complete' or ‘a lot' of relief of symptoms from their chiropractic treatments. Satisfaction with care was high, with 87 percent reporting levels of 8 or higher on a 10-point scale and 56 percent indicating a perfect score of 10. Similarly high proportions reported that chiropractors listened carefully and spent sufficient time with them." Low Back Pain
For more than half of patients seeking chiropractic care, low back pain is the primary reason. It is, therefore, not surprising that low back pain has been a central focus of chiropractic-related research. More than 80% of people experience low back pain at some time in their lives. For many, the condition becomes chronic. While studies on direct and indirect costs of low back pain vary widely in methodology and bottom line conclusions, and no definitive figures for the United States are available, the overall cost is understood to amount to at least tens of billions of dollars annually and perhaps hundreds of billions.10 Back pain is the leading cause of work-related disability and missed days of work. Moreover, chronic back pain is associated with reduced mobility, quality of life, and longevity,11 along with increased rates of a variety of other health problems.12 Conventional medicine has found the treatment of low back pain to be quite challenging and chiropractic has to an appre-ciable extent filled the resulting niche. National Low Back Pain Guidelines
The body of scientific studies on spinal manipulation for low back pain
is now broad and deep, as recognized by national assessment and
guidelines panels in the United States and other nations including Great
ChiroprACtiC reSeArCh And prACtiCe
Britain,13 Sweden,14 Denmark,15 and Australia.16 Basing their conclusions on several dozen randomized clinical trials of spinal manipulation, these expert panels (primarily composed of medical physicians) have correctly noted that manipulation has a verifiably strong record for successful y treating low back pain. RAND Appropriateness and Utilization Study
The first independent guideline on spinal manipulation for low back pain
was the influential RAND Appropriateness and Utilization Study,5 which
concluded in 1991 that manipulation was "appropriate" for acute low back
pain based on ratings by expert panels, which based their evaluations on
the existing scientific literature.
Agency for Health Care Policy and Research Guidelines
The 1994 Guidelines for Acute Lower Back Pain,17 developed for the
Agency for Health Care Policy and Research (AHCPR) of the U.S.
Department of Health and Human Services by a blue-ribbon panel
composed primarily of medical physicians and chaired by an orthopedic
surgeon (2 of the 23 members were chiropractors), included a powerful
endorsement of spinal manipulation.
Based on an extensive literature review and consensus process, the AHCPR Guidelines concluded that spinal manipulation "hastens recovery" from acute low back pain. Among dozens of nonsurgical therapies, the panel judged that only two had substantial scientific support—spinal manipulation and pain medications, such as analgesics and anti-inflammatory drugs. Of the two, the AHCPR Guidelines found that only spinal manipulation offers both "symptomatic relief" and "functional improvement." Thus, one may reasonably infer that for patients with acute low back pain who show none of the guidelines' diagnostic "red flags" (fractures, tumors, infections), manipulation is the treatment of choice.
American Pain Society/American Col ege of Physicians
In 2007, Annals of Internal Medicine published low back pain guidelines
jointly developed by the American Pain Society (APS) and the American
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College of Physicians (ACP).18 After thoroughly surveying and analyzing the available research, the all-medical APS-ACP panel recommended that for patients who do not improve with self-care options, doctors should consider the addition of non-pharmacologic therapy "with proven benefits." Spinal manipulation was one of eight methods recommended for chronic and subacute low back pain and was the only one of these also recommended for cases of acute low back pain.
Low Back Pain Research: Key Studies
Dozens of wel -designed research trials involving spinal manipulation for low back pain helped form the basis for the national guidelines just described. Among the most important are the fol owing: First Study on Chiropractic in a Medical Journal, Co-Authored
by Chiropractor and Medical Doctor (Canada, 1985)
A powerful study illustrating the value of chiropractic care for chronic
low back pain patients was performed at the University of Saskatchewan
hospital orthopedics department by Kirkaldy-Willis, a world-renowned
orthopedic surgeon, and Cassidy, a chiropractor who later became the
department's research director.19 The approximately 300 subjects in this
study were "totally disabled" by low back pain, with pain present for an
average of 7 years. All had gone through extensive, unsuccessful medical
treatment before participating as research subjects.
After 2 to 3 weeks of daily chiropractic adjustments, more than 80% of the patients without stenosis (spinal canal narrowing) had good to excellent results, reporting substantially decreased pain and increased mobility. After chiropractic treatment, more than 70% were improved to the point of having no work restrictions. Follow-up a year later demonstrated that the changes were long-lasting. Even those with a narrowed spinal canal, generally considered the most challenging cases, showed a notable response. More than half of these patients improved, and about one in five were pain-free and on the job 7 months after treatment.
ChiroprACtiC reSeArCh And prACtiCe
First Large Chiropractic Trial Published in
British Medical Journal (United Kingdom, 1990)
In the first large randomized clinical trial to demonstrate substantial
short-term and long-term benefits from chiropractic care, a team led by
orthopedic surgeon Meade compared chiropractic care and standard
hospital outpatient treatment in a trial with more than 700 patients.20, 21
Meade concluded that, "For patients with low-back pain in whom
manipulation is not contraindicated, chiropractic almost certainly confers
worthwhile, long-term benefit in comparison to hospital outpatient
management." He also stated, "One of the unexpected findings was that the
treatment difference—the benefit of chiropractic over hospital treatment—
actual y persists for the whole of that three-year period [of the study] … the
treatment that the chiropractors give does something that results in a very
long-term benefit."22
Chronic Low Back Pain Study (United States, 1995)
In a randomized trial of 209 patients published in Spine, Triano and
colleagues compared spinal manipulation to education programs for
chronic low back pain.23 These researchers found greater improvement
in pain and activity tolerance in the chiropractic group, reporting
that "immediate benefit from pain relief continued to accrue after
manipulation, even for the last encounter at the end of the 2-week
treatment interval." They concluded, "There appears to be clinical value
to treatment according to a defined plan using manipulation even in
low back pain exceeding 7 weeks duration."
Spinal Manipulation Outperforms Acupuncture and
Medication (Australia, 2003)
In a study of 115 patients with chronic spinal pain, Giles and Muller
compared the effects of medication (NSAID or analgesic not previously
ineffective for the individual patient), spinal manipulation, and
acupuncture.24 Treating practitioners were told to follow their normal
office procedures to determine whether manipulation or acupuncture was
appropriate and to determine which adjustive procedures or acupuncture
points should be used. The highest proportion of early recovery was found
for manipulation (27.3%), followed by acupuncture (9.4%) and medication
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(5%). A follow-up study found that "in patients with chronic spinal pain syndromes, spinal manipulation, if not contraindicated, may be the only treatment modality of the assessed regimens that provides broad and significant long-term benefit."25 Chiropractic Yields Outcomes Superior to Medical Care
(United States, 2004)
In a practice-based research study of 2870 patients with acute and
chronic low back pain who visited either medical or chiropractic physicians'
offices and received customary care, Haas and col eagues found consistent
evidence of superior outcomes for those receiving chiropractic care.26
Acute patients demonstrated greater relief at all time points. A clinically
important advantage for chiropractic patients was seen in chronic patients
in the short-term, and both acute and chronic chiropractic patients
experienced somewhat greater relief up to 1 year. The advantage for the
chiropractic group was prominent for chronic patients with leg pain below
the knee.
First Dose-Response Study on Chiropractic for
Chronic Low Back Pain (United States, 2004)
In the first trial to evaluate the effects of different frequency schedules for
chiropractic visits in cases of chronic low back pain, a pilot study by Haas
and colleagues27 randomly allocated 72 patients to different schedules of
visits (1, 2, 3 or 4 visits per week for 3 weeks). At 4 weeks, there was a
substantial trend demonstrating superior benefits with a larger number
of visits. Relief was greatest for patients receiving care 3 to 4 times per
week for 3 weeks.
Chiropractic Superior to Medical Care in British National
Health Service Hospital Study (United Kingdom, 2008)
A small but influential study by Wilkey et al28 featured a head-to-head
comparison of chiropractic care versus medical care for chronic low back
pain in a British National Health Service hospital pain clinic. The chiro-
practic and pain clinic groups started with similar levels of pain, although
the chiropractic group was on average a decade older than the medical
group and chiropractic subjects had endured their pain for a mean of
ChiroprACtiC reSeArCh And prACtiCe
three years longer (7 vs. 4 years). Nevertheless, improvement in pain intensity at week 8 was 1.8 points greater (on a zero to 10 scale) for the chiropractic group than for the pain clinic group, a substantial difference. Most importantly, disability scores demonstrated a much larger benefit from chiropractic care, with a greater than 5-fold difference in the degree of improvement. These data measured effects through the end of the 8-week treatment period. Within a year after the publication of this study, Great Britain's National Health Service changed its guidelines for chronic low back pain to include coverage for spinal manipulation. Two Chiropractic Techniques Outperform
Conventional Medicine for Low Back Pain in
Older Adults (United States, 2009)
In the first randomized controlled trial of chiropractic care for older
adults, and one of the first to compare different methods of chiropractic
adjustment to each other and to conservative medical care, Hondras et
al evaluated the effects of these three approaches for 240 people with
subacute and chronic low back pain.29 High-velocity and low-velocity
chiropractic techniques (combined with standardized exercise recommen-
dations) resulted in similar levels of improvement, with both chiropractic
methods substantially outperforming the medical care group, who
received the same exercise instructions along with pain medication.
Neck Pain
Neck pain is the second most common reason patients seek chiropractic care. While chiropractic care can be helpful to individuals with acute or chronic neck pain, at this time the research supporting spinal manipula-tion for chronic neck pain is stronger and more extensive than for acute cases. To put this into context, it should be understood that chiropractic is not unique in this respect; no other treatments for acute neck pain have strong research support. RAND Appropriateness Study for Chronic Neck Pain (1995)
The RAND Corporation conducted both a literature review and a
multidisciplinary panel appropriateness study for neck pain.30 This RAND
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report stated that spinal manipulation could deliver short-term pain relief and improved range of motion for subacute or chronic neck pain, while concluding that research on acute neck pain was too limited to reach any conclusion. World Health Organization Bone and Joint
Decade Report (2008)
By far the most comprehensive recent evaluation of all neck pain
therapies was performed by the Bone and Joint Decade 2000–2010
Task Force on Neck Pain and Its Associated Disorders.31 In the panel's
report on noninvasive interventions, it concluded that, "Our best evidence
synthesis suggests that therapies involving manual therapy and exercise
are more effective than alternative strategies for patients with neck pain;
this was also true of therapies which include educational interventions
addressing self-efficacy." Because chiropractors consistently include
exercise advice and share relevant self-care educational materials with
patients as part of overall care,32 chiropractic management of neck
pain substantially embodies the full range of noninvasive therapeutic
approaches recommended by the Bone and Joint Decade Task Force.
Neck Pain Research: Key Studies
Manual Therapy Superior to Comparison Treatments
and Placebo (Netherlands, 1993)
A team of Dutch researchers led by Koes33 studied patients with
persistent back and neck complaints. In a randomized trial, they were
treated with either manual therapy (spinal manipulation and mobilization),
physiotherapy (exercises, massage, electrotherapy, ultrasound, shortwave
diathermy), treatment by the general practitioner (analgesics, posture
advice, home exercise and bedrest), or a placebo treatment consisting of
detuned shortwave diathermy and detuned ultrasound. For neck and back
complaints together, improvements in severity of the main complaint were
larger with manipulative therapy than physiotherapy; for neck complaints
only, the mean improvement in the main complaint as shown by the visual
analog scale was slightly better for manipulative rather than physical
therapy. Both manual therapy and physiotherapy (both of which are part
ChiroprACtiC reSeArCh And prACtiCe
of the chiropractor's scope of practice) were superior to medical care and placebo. In this study, the placebo yielded results superior to medical care. Chiropractic Manual Methods Plus Exercise
Helpful for Chronic Neck Pain (Sweden, 2006)
In a randomized clinical trial, Palmgren et al found that a group of chronic
neck pain patients who received 15–25 chiropractic treatments over
a 5-week period had significantly lower pain scores and greater head
repositioning accuracy than another group with the same condition given
a similar examination but no treatment.34 Chiropractic care included
high- and low-velocity techniques, myofascial release, and spine-stabilizing
exercises. The researchers concluded that chiropractic care could be
effective in reducing pain originating in the cervical spine—as wel as
enhancing proprioceptive sensibility (movement and position sense).
A series of studies have shown chiropractic to be an effective treatment for headaches. Because headaches can develop from a variety of causes, alone or in combination, a holistic approach that considers all possible causes is desirable. Such causes may include spinal joint dysfunction (subluxation), muscular imbalance and tension, negative reactions to foods or medications, sleep disturbances, emotional stress, or chemical irritants in the water or air. Duke University Headache Report, Cochrane Review
In 2001, the Duke University Center for Health Policy Research and
Education completed Evidence Report: Behavioral and Physical
Treatments for Tension-type and Cervicogenic Headache
,35 based on
a comprehensive review of all available headache research. Among its
conclusions were that (1) in comparison to the use of the medication
amitriptyline, chiropractic produces slightly less improvement during the
treatment period, but markedly superior long-term results in the treat-
ment of tension-type headache and (2) compared to various soft tissue
procedures, a course of manipulation treatments produces sustained
improvement in headache frequency and severity in the treatment of
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cervicogenic headache (pain originating in the neck and referred to the head). A 2004 systematic review of headache research for the Cochrane Collaboration, Noninvasive Physical Treatments for Chronic/Recurrent Headaches,36 reached conclusions similar to the Duke report. Headache Research: Key Studies
After Treatment Stops, Effects Last Far Longer from
Chiropractic than Medication (United States, 1995)
In a randomized clinical trial that was later recognized by a Scandinavian
rheumatology journal37 as an extremely high quality study, Boline and
colleagues found that one month of chiropractic care (approximately
2 visits per week) was more effective than the medication amitriptyline
for long-term relief of headache pain.38 During the treatment phase
of the trial, pain relief among those treated with medication was
roughly comparable to the chiropractic group. But chiropractic patients
maintained their levels of improvement after treatment was discontinued,
while those taking medication returned to pretreatment status in an
average of 4 weeks after its discontinuation. This strongly implies that
while medication suppressed the symptoms, chiropractic addressed the
problem at a deeper, more causal level.
Cervicogenic Headaches Respond to Spinal Manipulation
(Denmark, 1997)
A randomized clinical trial by Nilsson et al39 evaluated the effectiveness
of spinal manipulation for cervicogenic headache. Researchers compared
groups given either high-velocity cervical spinal manipulation or low-level
laser treatment and found statistical y significant improvement for the
chiropractic group in terms of decreased pain, headache hours per day and
use of pain medication.
Chiropractic Helpful for Migraines (United States, 1998)
A randomized trial by Nelson and colleagues40 in which chiropractic
adjustments were compared to amitriptyline, demonstrated that migraine
headaches were responsive to chiropractic care and that adding amitrip-
tyline to chiropractic treatment conferred no additional benefit.
ChiroprACtiC reSeArCh And prACtiCe
Study Confirms Chiropractic's Value for Migraines
(Australia, 2000)
In a randomized controlled trial lasting 6 months, Tuchin et al41
compared manipulation to detuned ultrasound. Two months of chiro-
practic adjustments (maximum of 16 treatments) yielded statistically
significant improvement in migraine frequency, duration, disability and
medication use.
Dose-Response Study on Headaches Indicates Need for
Adequate Number of Visits (United States, 2004)
Seeking to determine the proper frequency of chiropractic treatments for
headache patients, Haas and col eagues randomly al ocated 24 adults with
cervicogenic headache into groups visiting a chiropractor 1, 3, or 4 times
per week over a 3-week period.42 All patients received high-velocity, low-
amplitude manipulations plus up to two physical modalities including heat
and soft tissue therapy. Greater pain relief was seen at 4 and 12 weeks
for the patients receiving 9 and 12 treatments than for those receiving 3,
demonstrating that continuing treatments for up to 9–12 treatments
conferred additional benefits.
Chiropractors' focus on the spine is enhanced through attention to the role of the extremities (arms and legs). Since the earliest days of the profession, doctors of chiropractic have adjusted extremity joints. In some cases, this is to address local problems at, for example, the ankle, knee, or shoulder. In other cases, the goal is to influence the overall balance of the body, including the spine. Causation runs in both directions—spinal adjustments can influence the extremities, and extremity manipulation can influence the spine.
Two comprehensive reviews have evaluated the status of extremity manipulation research, which is currently much less extensive than research on manipulation of the spine. StAte of the Art
Council on Chiropractic Guidelines and
Practice Parameters (2009)
Brantingham and colleagues,43 an expert panel appointed by the Scientific
Commission of the Council on Chiropractic Guidelines and Practice
Parameters (www.ccgpp.org), reviewed all available research on lower
extremity conditions and found fair evidence for manipulative therapy of
the knee and/or full kinetic chain, and of the ankle and/or foot, combined
with multimodal or exercise therapy for knee osteoarthritis, patel-
lofemoral pain syndrome, and ankle inversion sprain. They found limited
evidence for manipulative therapy of the ankle and/or foot combined
with multimodal or exercise therapy for foot conditions such as plantar
fasciitis, metatarsalgia, and hallux limitus/rigidus.
United Kingdom Evidence Report (2010)
Bronfort et al, in their comprehensive 2010 UK Evidence Report,44
included a review of research on manual therapies for upper and lower
extremity problems. For lower extremity conditions, they reached
conclusions quite similar to the Brantingham review. For upper extremity
conditions (which were not included in the Brantingham review), Bronfort's
group found moderate evidence supporting the addition of manipulation
or joint mobilization to usual medical care for shoulder girdle pain; incon-
clusive evidence in a favorable direction on manipulation/mobilization for
rotator cuff pain; moderate evidence that long-term benefits from elbow
mobilization with exercise exceed those from corticosteroid injections;
and inconclusive evidence in a favorable direction for manipulation and
mobilization in the treatment of carpal tunnel syndrome.
Key research trials that helped form the basis for these reviews and guidelines include the fol owing: Three Studies: Manipulation Helpful for
Certain Cases of Shoulder Pain
In a 1997 study from the Netherlands published in British Medical
Journal
, Winters and col eagues found that for "shoulder girdle" pain,
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manipulation was superior to physical therapy, while for "synovial" pain at the shoulder's bal -and-socket joint, corticosteroid injections were the most effective approach.45 Another Dutch study, published in 2004 in Annals of Internal Medicine by Bergman et al,46 found that adding manipulative therapy to usual medical care yielded superior outcomes in patients with shoulder dysfunction and pain. And in a 2007 study from the United States published in Journal of the American Chiropractic Association, Munday and col eagues conducted a randomized, single-blinded, placebo-controlled clinical trial47 on shoulder impingement syndrome, in which one group received shoulder adjustments and the other a placebo (detuned ultrasound). Participants were treated 8 times over 3 weeks, resulting in a significant pain reduction for the group receiving chiropractic care.
Hip Manipulation Effective for Hip Osteoarthritis
(United States, 2004)
The one major study on hip manipulation was conducted by Hoeksma
and colleagues,48 who compared hip manipulation and mobilization to an
exercise program. Patients were treated once a week for 9 weeks. Success
rates (perceived improvement) after 5 weeks were 81% in the manual
therapy group and 50% in the exercise group. Patients in the manual
therapy group had significantly better outcomes on pain, stiffness, hip
function, and range of motion. Effects of manual therapy on the improve-
ment of pain, hip function, and range of motion endured after 29 weeks.
Two Studies Indicate Manual Therapy Effectiveness
for Knee Osteoarthritis (United States, 2000 and 2005)
At a military medical center in Texas, Deyle and colleagues49 compared a
program of manual therapy (applied to the knee as well as to the lumbar
spine, hip, and ankle as required), plus standardized knee exercises
to a placebo involving sub-therapeutic ultrasound applied to the knee.
Clinically and statistically significant improvements in 6-minute walk
distance and WOMAC score (for osteoarthritis symptoms) at 4 weeks and
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8 weeks were seen in the treatment group but not the placebo group. By 8 weeks, average 6-minute walk distances had improved by 13.1% and WOMAC scores had improved by 55.8%. At 1 year, patients in the treat-ment group had clinically and statistically significant gains over baseline WOMAC scores and walking distance; 20% of patients in the placebo group and 5% of patients in the treatment group had undergone knee surgery. The researchers concluded that "a combination of manual physical therapy and supervised exercise yields functional benefits for patients with osteoarthritis of the knee and may delay or prevent the need for surgical intervention." Deyle et al's large study on knee osteoarthritis50 compared a home-based physical therapy regime with a clinic-based program that included both supervised exercise and manual therapy. These investigators concluded that a home exercise program was effective for patients with osteoarthritis of the knee and that clinical visits with manual therapy and supervised exercise increased the benefit.
Manipulation Superior to Placebo for Ankle Sprain
(Union of South Africa, 2001)
Pellow and Brantingham performed the first chiropractic trial on ankle
inversion sprains,51 comparing results of an ankle mortise separation
adjustment to a placebo intervention of detuned ultrasound. Patients
received 8 treatment sessions over 4 weeks. The researchers found that
"although both groups showed improvement, statistically significant
differences in favor of the adjustment group were noted with respect to
reduction in pain, increased ankle range of motion, and ankle function."
For Ankle Sprains, RICE Plus Mobilization Superior
to RICE Alone (United States, 2001)
Standard treatment for ankle sprains is based on the RICE (rest, ice,
compression and elevation) protocol. Green et al found that adding mobi-
lization to RICE was more effective than RICE alone for decreasing pain
and increasing ankle mobility.52 Patients were treated every second day
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for 2 weeks or until discharge criteria were met. The experimental group had greater improvement in range of movement before and after each of the first 3 treatment sessions. The experimental group also had greater increases in stride speed during the first and third treatment sessions.
ATHLETIC INJURY PREVENTION
Chiropractic Care Brings Major Decrease in Leg Injuries
(Australia, 2010)
In a groundbreaking 2010 study,53 chiropractic researchers Hoskins and
Pollard demonstrated that adding chiropractic care to standard medical
and physical therapy approaches significantly decreased the number of
leg injuries and missed games among Australian professional football
players.
Since chiropractic's earliest days, there have been numerous reports of individual cases where nonmusculoskeletal conditions appear to have responded positively to chiropractic care, in some cases dramatically. These types of responses, while numerous, have been sporadic and largely unpredictable. In addition to case reports and case series in the scientific literature, there have also been a small number of randomized controlled trials showing notable benefits from spinal adjustments for certain visceral disorders. Among these conditions are infantile colic, hypertension and cervicogenic vertigo (dizziness originating in the neck). Further research is needed before conclusions can be reached about the effectiveness of spinal manipulation for these and other visceral disorders.
Review of Chiropractic Care for Nonmusculoskeletal Problems
Hawk and colleagues evaluated research on chiropractic care for non-
musculoskeletal disorders in a 2007 review published in The Journal of
Alternative and Complementary Medicine.
54 Using methods that incorpo-
rated the effects of the full clinical encounter rather than spinal manipula-
tion alone, they found a somewhat wider range of nonmusculo skeletal
conditions helped by chiropractors, including asthma, cervicogenic vertigo,
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and infantile colic, while categorizing as "promising for potential benefit" the application of manual procedures for children with otitis media and elderly patients with pneumonia.
Chiropractic Adjustments Far Superior to Standard Medication
(Denmark, 1999)
Infantile colic, which occurs in approximately one-fifth of newborns,
involves prolonged, intense, high-pitched crying and is believed to be of
gastrointestinal origin. In a Danish study at the University of Odense,
Wiberg and colleagues performed a randomized clinical trial55 in which
colicky babies were given either very gentle spinal manipulation or dime-
thicone, an anti-foaming agent used in medical treatment of colic. Subjects
were recruited by health visitor nurses from Denmark's National Health
Service, which integrates chiropractic care. Treatment lasted 2 weeks. By
day 12, hours of crying decreased by 66% for the chiropractic group and
38% for the medication group.
Upper Cervical Chiropractic Method Helpful for Hypertension
(United States, 2007)
In a recent example of medical-chiropractic collaboration, Dickholtz, a
chiropractor, and Bakris, a medical hypertension specialist, published
a study in which upper cervical (neck) chiropractic adjustments led to
sustained improvement in chronic hypertension patients, "similar to that
seen by giving two different anti-hypertensive agents simultaneously," with
88% of subjects in the treatment group experiencing an 8mm Hg drop in
diastolic blood pressure.56 All subjects were taken off their hypertension
medications prior to the study and 85% of the patients in the chiropractic
treatment group required only one adjustment to yield these benefits
through the full 8 weeks of the study. Other studies on chiropractic care
for hypertension have yielded far less satisfactory results57 and efforts are
currently underway to determine whether positive findings of the Bakris-
Dickholtz study can be replicated.
ChiroprACtiC reSeArCh And prACtiCe
Indications That Neck-Related Vertigo Responds to
Manual Methods (Australia, 2005)
In a review of 9 studies on possible benefits of manual therapy for
patients with cervicogenic vertigo,58 Reid et al assessed the validity and
findings of the studies, expressed dissatisfaction with their quality, and
noted that "a consistent finding was that all studies had a positive result
with significant improvement in symptoms and signs of dizziness after
manual therapy treatment."
Comparative Safety of Chiropractic
Chiropractic has an excellent safety record but no healthcare method is completely free of risk. If spinal manipulation were a prescription medica-tion, its rate of major adverse effects would justify calling it remarkably safe. The area of greatest controversy is vertebrobasilar accident (VBA), or stroke. Chiropractic students are taught best practices for recognizing impending strokes, appropriate care and caution are given strong empha-sis, and the profession endorses the use of informed consent. Full understanding of this issue hinges on the question of whether the rare stroke that occurs following a visit to a chiropractor was actually caused by chiropractic treatment or occurred for reasons not associated with it. Only recently has large-scale, rigorous research addressed this issue, with two large reviews of all records in the Canadian province of Ontario. Because Canada has publicly-funded universal healthcare, this data is presumed to be comprehensive. Questions of a possible causative role for spinal manipulation raised in the first study, by Rothwell et al59 appear to have been fully resolved in the later Cassidy et al study.60 Rothwell Study (Canada, 2001)
Rothwell et al59 reviewed all records from 1993–1998 and found a total
of 582 vertebrobasilar accident cases in the province. Each was age and
gender matched to 4 controls from the Ontario population with no history
of stroke at the event date. Public health insurance billing records were
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used to document utilization of chiropractic services during the year prior to VBA onset. Slightly more than 90% had no chiropractic visits in the year preceding their VBA. Of the 57 individuals with VBAs who did visit a chiropractor in the 365 days preceding the VBA (out of 50 million chiro-practic visits during the 5-year period studied), 27 are believed to have had cervical manipulation. Of these, 4 individuals visited a chiropractor on the day immediately preceding the VBA, 5 in the previous 2–7 days, 3 in the previous 8–30 days, and 15 in the previous 31–365 days. Compared to the controls, there was an increased association of VBA among patients who saw a chiropractor 1–8 days prior to the VBA event, but a decreased association of CVA among patients who saw a chiropractor 8–30 days before the event. Rothwell et al found no association between recent chiropractic visits and VBAs in patients over age 45. However, patients under age 45 were 5 times more likely to have visited a chiropractor within the week prior to the VBA and 5 times more likely to have had 3 or more visits with a cervical diagnosis in the month preceding the VBA. Though Rothwell and colleagues explicitly cautioned against using their data to infer a cause-and-effect relationship between spinal manipulation and stroke, some used their data to make such a connection. There were a total of 6 strokes within 7 days of neck manipulation in the under-45 group, out of approximately 15 million total neck manipulations during the time period evaluated.
Cassidy Study (Canada, 2008)
Several years after the Rothwell study, Cassidy and colleagues60
completed a review of the same Ontario records evaluated by Rothwell's
group and extended the time period covered in the review by three
years. They performed additional analyses to determine whether patients
who had seen a chiropractor were more likely to have had a stroke than
patients who had seen a medical physician. This question, which had not
been part of the earlier Rothwell review, was crucial because patients in
the early stages of a stroke commonly experience symptoms (headache,
neck pain) that may lead them to consult either a chiropractor or a
medical doctor.
ChiroprACtiC reSeArCh And prACtiCe
Cassidy's group found that it was no more likely for a stroke patient to have seen a chiropractor than a medical physician. In fact, those visiting a medical doctor rather than a chiropractor were more likely to have had a stroke, although this difference was not statistically significant. The authors concluded, "The increased risks of VBA stroke associated with chiropractic and PCP [primary care physician] visits is likely due to patients with headache and neck pain from VBA dissection seeking care before their stroke. We found no evidence of excess risk of VB stroke associated [with] chiropractic care compared to primary care." While the primary consideration for any form of treatment is clinical effectiveness (improvement in the patient's condition), cost-conscious patients, insurers, and policy makers also look closely at cost-effective-ness in evaluating healthcare options. Chiropractic fares quite well in such comparisons.
Mercer Report: Chiropractic Is the Most Cost-Effective Approach
for Low Back and Neck Pain (United States, 2009)
Niteesh Choudhry, MD, PhD, of Harvard Medical School, and Arnold
Milstein, MD, Chief Physician at Mercer Health and Benefits and Medical
Director of the Pacific Business Group on Health, co-authored the 2009
report, Do Chiropractic Physician Services For Treatment of Low-Back
and Neck Pain Improve the Value of Health Benefit Plans? An Evidence-
Based Assessment of Incremental Impact on Population Health and
Total Healthcare Spending
.61 This report combined a rigorous analysis
of direct and indirect costs with equally relevant (though often missing
from such analyses) evidence concerning clinical effectiveness. In other
words, Choudhry and Milstein started with the assumption that low
cost is only a virtue if a product or service effectively delivers what it
promises. Including both clinical effectiveness and cost in their analysis,
they concluded that chiropractic care was far more valuable than medical
treatment for neck and low back pain.
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These analysts found that for neck pain, chiropractic physician care decreases annual spending by $302 compared to medical physician care, and that for low back pain, chiropractic increases total annual per patient spending by $75 compared to medical physician care. Their analysis also noted that chiropractic care, particularly when combined with exercise, is significantly more effective than medical care for patients for low back and neck pain. This combination of factors led them to conclude that, "when considering effectiveness and cost together, chiropractic physician care for low back and neck pain is highly cost effective, represents a good value in comparison to medical physician care and to widely accepted cost-effectiveness thresholds. Because we were unable to incorporate savings in drug spending commonly associated with US chiropractic care, our estimate of its comparative cost-effectiveness is likely to be understated." Chiropractors in Primary Care Role Help Cut Costs
(United States, 2004, 2007)
A collaborative 7-year research project led by Sarnat, a medical
physician, and Winterstein, a chiropractic physician, documented that
patients in an integrative independent practice association—whose
primary care physicians (PCPs) were doctors of chiropractic and
CAM-oriented medical doctors with a primarily nonsurgical and
nonpharmaceutical approach—were able to achieve substantial cost
savings in comparison to patients whose PCPs (in the same health
maintenance organization in the same time frame) used conventional
medicine alone. Clinical and costs utilization based on 70,274 member-
months over a 7-year period demonstrated decreases of 60.2% for
in-hospital admissions, 59.0% for hospital days, 62.0% for outpatient
surgeries and procedures, and 85% for pharmaceutical costs.62, 63
Manga Reports: Chiropractic Far More Cost-Effective than
Medical Care for Low Back Pain (Canada, 1993, 1998)
Twice in the 1990s, University of Ottawa health economist Pran
Manga was commissioned by the government of Ontario to assess
the effectiveness and cost-effectiveness of chiropractic management of
low-back pain.64, 65 His assessment of the comparative cost data in his
ChiroprACtiC reSeArCh And prACtiCe
first report led him to conclude that, "There is an overwhelming body of evidence indicating that chiropractic management of low-back pain is more cost-effective than medical management. We reviewed numerous studies that range from very persuasive to convincing in support of this conclusion. The lack of any convincing argument or evidence to the contrary must be noted and is significant to us in forming our conclusions and recommendations." The cost advantages for chiropractic for matched conditions were so impressive that Manga, in his second report, concluded that doubling the utilization of chiropractic services from 10% to 20% could result in savings of as much as $770 mil ion annual y in direct costs and $3.8 bil ion in indirect costs.
Recent Chiropractic Advances:
Integration & Inclusion
Among the most promising developments in the mainstreaming of chiropractic is the recent inclusion of chiropractic in the healthcare systems serving veterans and active-duty military personnel. Starting with successful pilot programs in the 1990s, both the Veterans Administration (VA) and Department of Defense now include chiropractic services as an integral part of the healthcare available to veterans and active duty members of the military. As of 2010, chiropractors were serving in official capacities at approximately 36 VA hospitals and 60 military treatment facilities in the U.S and overseas. Retired General Becky Halstead, the first female graduate of West Point to be promoted to Brigadier General and the first woman to command in combat at the strategic level, is among chiropractic's most enthusiastic advocates. Gen. Halstead puts it this way: "The year I was deployed to Iraq I missed my friends and family—and my chiropractor! The hands-on active care of doctors of chiropractic and their advice on a healthy lifestyle are essential to our military men and women." StAte of the Art
Chiropractors are now an integral part of the sports medicine staffs for the Olympic Games and teams in the National Football League, National Basketball Association and Major League Baseball, as well as collegiate, scholastic and youth club sports. Doctors of chiropractic are well trained to address the needs of athletes from a wide variety of individual and team sports. The chiropractor's knowledge of neuromusculoskeletal disorders makes chiropractic care a perfect fit for the prevention and treatment of most sport-related injuries.
Reflecting this expertise, 2010 marked the first time that chiropractors occupied the two top leadership positions for the U.S. Olympic Committee (USOC) medical team—with Michael Reed, DC, serving as USOC Medical Director, and Bill Moreau, DC, as USOC Director of Sports Medicine Clinics.
Business and Industry
The musculoskeletal ailments effectively treated by chiropractors (back pain, neck pain, headaches and extremity problems) are the leading cause of work-related disability and missed days of work, which adversely impacts workers' well-being and the corporate bottom line. As a result, many small and large employers seek out chiropractors as consultants and, in some cases, as full-time medical staff members. Aside from treating injured workers and those with other painful conditions, chiropractors' expertise in workplace ergonomics and wellness counseling provides an essential service for corporations desiring to keep their employees healthy.
Prevention and Health Promotion
In keeping with their holistic approach to healthcare, chiropractors encourage patients to take an active role in restoring and maintaining health, with particular emphasis on doctor-guided self-care through ChiroprACtiC reSeArCh And prACtiCe
exercise and nutrition.66 The American Public Health Association includes a Chiropractic Healthcare Section that focuses on public health issues such as wellness, health promotion and disease prevention in the context of chiropractic policies and practices. In addition, the Council on Chiropractic Education now mandates that all students graduating from chiropractic colleges demonstrate knowledge of evidence-based prevention and mastery of methods for applying these approaches with patients. This report was researched and written by Daniel Redwood, DC. Special thanks to Cheryl Hawk, DC, PhD; Anthony Rosner, PhD; J. Michael Flynn, DC; and Carl S. Cleveland III, DC, for reviewing the manuscript. 2010 by Cleveland Chiropractic College–Kansas City and Los Angeles. All rights reserved. www.cleveland.edu 1. Chapman-Smith DA. The Chiropractic Profession. Des Moines: NCMIC
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Microsoft powerpoint - statin template july 2012 v2.7.ppt

Statin Template GuidanceUse of statins in primary and secondary prevention of vascular disease Notes relating to this guidance This guidance serves as an aid to the implementation of NICE clinical guidelines on lipid modification (CG67) and type 2 diabetes (CG66). Please note that NICE CG67 is currently being updated and this guidance document will be subject to review upon publication.

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The Thought Leadership Series Kent Monroe Price and perceived value Understanding how your customers form value perceptions A successful proactive pricer sets price to be consistent with customers´ perceived value. To understand how customers form value perceptions, it is important to recognize the role of price. Because of the difficulty of