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An analysis of generic competition in the UK pharmaceuticals market. Does aggressiveness of entry affect prices in the post generic entry period?∗ Charles A. Ngoh, Datamonitor Plc Tel: 07748322856; email:cngoh@datamonitor.com Despite being regulated through the Statutory Maximum Price Scheme which, in essence stipulates the maximum reimbursement price for generic pharmaceutical products, prices of

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Christchurch Medical Research Society AGM and Scientific Meeting Wednesday 24 April 2002 5 pm - 7.30 pm in the Rolleston Lecture Theatre 5.00 ANNUAL GENERAL MEETING 5.15 ORAL PRESENTATIONS 5.15 VEGF-D expression is associated with lymph node status in primary human breast carcinomas and regulated by estrogen in breast carcinoma cell lines Margaret J Currie*, Sarah P Gunningham, Vickie Hanrahan, Helen R Morrin, Prudence A E Scott, Bridget A Robinson, Stephen B Fox

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Medical Marijuana - When Human Rights and Safety Laws Collide When does an employer's right to know, and their legal obligation to take every precaution reasonable to protect the safety of the worker, overshadow a worker's rights to privacy and confidentiality? Or does it? Recent medical developments are potentially putting workers and employers at risk.and sorting through the complications will require a great deal of time and effort. The legalization of medical marijuana, and the sharp increase in prescriptions over the past few years, will have a profound effect on workplace health and safety policies and procedures for all companies in the future. According to many sources, over 400,000 Canadians will be taking medical marijuana within a decade. This is an issue that will eventually affect almost every workplace in the country. The sooner you prepare for it, the better you will be able to handle the situation correctly and legally, when it arises at your organization. Potential Uses and Users Medical marijuana is currently being prescribed in Canada to treat the following: Palliative care, chronic nausea and vomiting, wasting syndromes related to AIDS and cancer treatments, Anorexia Nervosa, Dystonia, Migraine Headaches, Multiple Sclerosis, ALS, Epilepsy, Acute and/or Chronic Pain, Arthritis, Musculoskeletal Disorders, Fibromyalgia, Osteoporosis, Huntington's Disease, Parkinson's Disease, Tourette Syndrome, Glaucoma, Asthma, Hypertension, Depression, Anxiety, Sleep Disorders, Post-Traumatic Stress Disorder, Schizophrenia, Inflammatory Skin Diseases, Alzheimer's Disease, Irritable Bowel Syndrome, Crohn's Disease, Liver Diseases and Pancreatic Diseases. This list is being added to on a regular basis as more is learned of the beneficial effects of marijuana treatment on a variety of illnesses and symptoms. This Is NOT a New Situation! The drug in question may be different, but most of the concerns and risks we are discussing are actually old news. Many workers show up to their jobs every day, while taking prescription drugs that affect their performance and mental acuity. The list of "psychoactive" (or "psychotropic") medicines is very long. Some of the most common are Percocet, OxyContin, Dilaudid, Valium, Xanax, Ativan, Vicodin, Zoloft and Wellbutrin.

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Forschung · WissenschaftRecherche · Science Assistant Editor Rédacteur en chef Jürg Meyer, Basel Urs Belser, Genève Tuomas Waltimo, Basel Rudolf Gmür, ZürichPeter Hotz, Bern Advisory board / Gutachtergremium / Comité de lecture P. Baehni, Genève K.H. Jäger, Basel M. Perrier, Lausanne J.-P. Bernard, Genève

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neue Möglichkeiten und chAncen Unerwünschte Vareniclin Plazebo Raucherentwöhnung Ereignisse (in %) (in %)Übelkeit Medikamente können die Chancen auf eine erfolgreiche Nikotin-Entwöhnung erhöhen. Zur Verfügung stehen Nikotinpflaster, Bupropion und neuerdings auch Vareniclin. Der Cannabinoid-Rezeptorantagonist Rimonaband, der in Studien ebenfal s einen

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The Journal of Neuroscience, August 1, 2002, 22(15):6321–6324 Caffeine Induces Dopamine and Glutamate Release in the Shell ofthe Nucleus Accumbens Marcello Solinas,1 Sergi Ferre´,1 Zhi-Bing You,2 Marzena Karcz-Kubicha,1 Patrizia Popoli,3 andSteven R. Goldberg1 Sections of 1Preclinical Pharmacology and 2Behavioral Neuroscience, Behavioral Neuroscience Branch, National Instituteon Drug Abuse, National Institutes of Health Intramural Research Program, Baltimore, Maryland 21224, and3Department of Pharmacology, Istituto Superiore di Sanita, 00161 Rome, Italy

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Harmer's Haven Residents and Ratepayers Group Minutes of meeting of AGM Sunday 31 March 31 2013 11.00 am, 86 Viminaria Road Present: Ros Eason, Rosemary Paterson, Tom Patterson, Amaryl Perlesz, Val Grant,Ron Thomas, Cristine Larner, Luciano Furfaro, John Old, Luisa Macmillan, RichardTanter, Corinn Lim. Apologies: Helen Collyer, Suzie Walker, Diane McLaughlin, Uly Michel, Dave Lane,Maria Zerella, Aneta Marovich, Sally Murray Whiting, Geoff Whiting, Judy and TerryPederson.Visitors Neil Rankine (councilor), David Hol yfield, Jessica (Shut the Gate campaign)(attended later).

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The Sec6兾8 complex in mammalian cells: Characterization of mammalian Sec3,subunit interactions, and expressionof subunits in polarized cellsHugo T. Matern*, Charles Yeaman†, W. James Nelson†, and Richard H. Scheller*‡ *Genentech, Inc., Department of Richard Scheller, 1 DNA Way, South San Francisco, CA 94080-4990; and †Department of Molecular and Cellular Physiology,Stanford University Medical School, Stanford, CA 94305

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NFATc1 Balances Quiescence andProliferation of Skin Stem CellsValerie Horsley,Antonios O. Aliprantis,Lisa Polak,Laurie H. Glimcher,and Elaine Fuchs,1Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University,New York, NY 10065, USA2Department of Infectious Diseases and Immunology, Harvard School of Public Health, Boston, MA 02115, USA3Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA*Correspondence: DOI 10.1016/j.cell.2007.11.047

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© Med Sci Monit, 2005; 11(12): SR27-31 The growth of a lie and the end of "conventional" Accepted: 2005.09.28Published: 2005.12.01 Domenico Mastrangelo1, Cosimo Loré2 1 Department of Ophthalmology, University of Siena, Italy2 Department of Forensic Medicine, University of Siena, Italy Source of support: Self fi nancing Throughout its over 200-year history, homeopathy has been proven effective in treating diseases for which conventional medicine has little to offer. However, given its low cost, homeopathy has always represented a serious challenge and a constant threat to the profi ts of drug companies. Moreover, since drug companies represent the most relevant source of funding for biomedical re-search worldwide, they are in a privileged position to fi nance detractive campaigns against home-opathy by manipulating the media as well as academic institutions and the medical establishment. The basic argument against homeopathy is that in some controlled clinical trials (CCTs), compari-son with conventional treatments shows that its effects are not superior to those of placebo. Against this thesis we argue that a) CCT methodology cannot be applied to homeopathy, b) misconduct and fraud are common in CCTs, c) adverse drug reactions and side effects show that CCT meth-odology is deeply fl awed, d) an accurate testing of homeopathic remedies requires more sophis-ticated techniques, e) the placebo effect is no more "plausible" than homeopathy, and its real na-ture is still unexplained, and f) the placebo effect is nevertheless a "cure" and, as such, worthy of further investigation and analysis. It is concluded that no arguments presently exist against home-opathy and that the recurrent campaigns against it represent the specifi c interests of the pharma-ceutical industry which, in this way, strives to protect its profi ts from the "threat" of a safer, more effective, and much less expensive treatment modality.

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DENUNCIA CIUDADANA Señora Ruth Obando, Delegada Departamental del Ministerio del Ambiente y Recursos Naturales del Departamento de Chontales. Nosotros los abajo firmantes, ciudadanos y ciudadanas nicaragüenses todos mayores de edad, domiciliados en los municipios de Santo Domingo y Managua amparados en el artículo 2 de la Ley 217, Ley General de Medio Ambiente y los Recursos Naturales, que establece que toda

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PEDRO CÉSAR CANTÚ MARTÍNEZ* Medio ambiente y salud: un enfoque ecosistémico El concepto ecología, establecida en una interrelación con el resto de los seres vivos y su 1869, por Ernest Haeckel, un natu- hábitat; asimismo, con la estructura y funcionamiento ralista alemán, reconocido como pa- de los ecosistemas en general que lo acogen. De manera dre de la ecología, determina que es

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Lithium Insertion in Nanostructured TiO2(B) ANTHONY G. DYLLA, GRAEME HENKELMAN, AND KEITH J. STEVENSON* Department of Chemistry & Biochemistry, The University of Texas at Austin, Austin, Texas 78712, United States RECEIVED ON JUNE 12, 2012 to become feasible alternatives to current technology, but only if scientists can develop energy storage materialsthat offer high capacity and high rate capabilities. Chemists havestudied anatase, rutile, brookite and TiO2(B) (bronze) in bothbulk and nanostructured forms as potential Li-ion batteryanodes. In most cases, the specific capacity and rate of lithiationand delithiation increases as the materials are nanostructured.Scientists have explained these enhancements in terms of highersurface areas, shorter Liþ diffusion paths and different surfaceenergies for nanostructured materials allowing for more facilelithiation and delithiation. Of the most studied polymorphs,nanostructured TiO2(B) has the highest capacity with promising high rate capabilities. TiO2(B) is able to accommodate 1 Liþ per Ti,giving a capacity of 335 mAh/g for nanotubular and nanoparticulate TiO2(B). The TiO2(B) polymorph, discovered in 1980 by Marchand andco-workers, has been the focus of many recent studies regarding high power and high capacity anode materials with potential applicationsfor electric vehicles and grid storage. This is due to the material's stability over multiple cycles, safer lithiation potential relative to graphite,reasonable capacity, high rate capability, nontoxicity, and low cost (Bruce, P. G.; Scrosati, B.; Tarascon, J.-M. Nanomaterials for RechargeableLithium Batteries. Angew. Chem., Int. Ed. 2008, 47, 2930"2946). One of the most interesting properties of TiO2(B) is that both bulk andnanostructured forms lithiate and delithiate through a surface redox or pseudocapacitive charging mechanism, giving rise to stable high ratecharge/discharge capabilities in the case of nanostructured TiO2(B). When other polymorphs of TiO2 are nanostructured, they still mainlyintercalate lithium through a bulk diffusion-controlled mechanism. TiO2(B) has a unique open crystal structure and low energy Liþ pathwaysfrom surface to subsurface sites, which many chemists believe to contribute to the pseudocapacitive charging.

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Published Ahead of Print on April 25, 2016 as 10.1200/JCO.2015.62.4544 JOURNAL OF CLINICAL ONCOLOGY Dexamethasone and High-Dose Methotrexate ImproveOutcome for Children and Young Adults With High-RiskB-Acute Lymphoblastic Leukemia: A Report From Children'sOncology Group Study AALL0232Eric C. Larsen, Meenakshi Devidas, Si Chen, Wanda L. Salzer, Elizabeth A. Raetz, Mignon L. Loh,Leonard A. Mattano Jr, Catherine Cole, Alisa Eicher, Maureen Haugan, Mark Sorenson, Nyla A. Heerema,Andrew A. Carroll, Julie M. Gastier-Foster, Michael J. Borowitz, Brent L. Wood, Cheryl L. Willman,Naomi J. Winick, Stephen P. Hunger, and William L. Carroll

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Takeaway Food: In recent decades there has been an increase in the growth of the ‘informal eating out sector'; nationally one in six meals are now eaten out of the home with men deriving a quarter of their energy and women a fifth from these foods1. Restaurants, cafes, work canteens and other food outlets on average capture 27% of consumer expenditure2. More than £10 billion each

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Potential Benefit of Biventricular Pacing in Patients with Congestive Heart Failure and Ventricular Tachyarrhythmia Christoph Stellbrink, MD, Angelo Auricchio, MD, Bjo¨rn Diem, MD, Ole-Alexander Breithardt, MD, Michael Kloss, MD, Friedrich A. Scho¨ndube, MD, PhD, Helmut Klein, MD, Bruno J. Messmer, MD, and Peter Hanrath, MD Treatment of congestive heart failure (CHF) aims for