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J Med Syst (2012) 36:145–157DOI 10.1007/s10916-010-9454-7 Algorithms for the Automated Detection of DiabeticRetinopathy Using Digital Fundus Images: A Review Oliver Faust & Rajendra Acharya U. & E. Y. K. Ng &Kwan-Hoong Ng & Jasjit S. Suri Received: 23 January 2010 / Accepted: 28 February 2010 / Published online: 6 April 2010 # Springer Science+Business Media, LLC 2010

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TOP FIVE MISTAKES TO AVOID IN YOUR POISONED PATIENT Justine A. Lee, DVM, DACVECC, DABT www.vetgirlontherun.com In veterinary medicine, with any poisoned patient, the primary treatment for toxicant exposure should be decontamination and detoxification, along with symptomatic and supportive care. Initial steps when presented a poisoned patient should include immediate triage and stabilization, obtaining an appropriate history, performing a thorough physical examination, and initiating treatment (including decontamination and stabilization). Appropriate decontamination and therapy is indicated to improve the overall prognosis and outcome of the small animal poisoned patient. The use of decontamination, if and when appropriate, should be implemented to help prevent further toxicant absorption. Gastrointestinal decontamination (including emesis induction and/or administration of activated charcoal with a cathartic) is considered the best method of limiting absorption and preventing continued exposure to potential toxicosis in veterinary medicine. This is particularly beneficial with potentially harmful or life-threatening ingestions. It is imperative, however, to consider whether decontamination is appropriate, as it may be too late or contraindicated (resulting in potentially further harm). Evaluation of the potential risk associated with induction of emesis needs to be considered. Five key mistakes to avoid in the poisoned patient include:

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1. Internationales auf dem Schneeberg (2.355 m) 1° incontro internazionale di condottieri con animali da soma 1ère rencontre internationale des muletiers In Zusammenarbeit mit/in collaborazione con/ en collaboration avec Beladenes Saumtier Condottiero con mulo Transport de marchandises à mit „Samer" in einer da soma in una illustra- l'aide d'un cheval : bête de

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Is there a need for an expanded © 2011 Wolters Kluwer - Pharma Solutions All rights reserved, including that of translation into other languages. This booklet is protected by copyright. No part of this publication may be reproduced or transmitted in any form or by any means, electronically or mechanically, including photocopying, recording or any information storage or retrieval

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A Technology Review on Virtual Colonoscopy Virtual Colonoscopy: An Alternative Approach to Examination of the Entire Colon Jerome Z. Liang Departments of Radiology, Computer Science and Biomedical Engineering State University of New York, Stony Brook, NY 11794, USA We have developed a virtual colonoscopy system aiming toward mass screening for polyps through the entire colon. This work reviews the key technical components of the system. Introduction Colorectal carcinoma is the second leading cause of cancer-related deaths among men and women in the United States, following lung cancer, with 56,000 deaths reported in 1998 and an estimated over 130,000 new cases per year [21]. Unfortunately the symptoms of colon cancer, such as anemia and change in bowel habits, are neither sensitive nor specific. Diagnosed cancers are often in the later stage of development, resulting in a high mortality incidence. Most colon cancer probably arises from polyps, which can take 5 to 15 years for malignant transformation. Recent studies have shown that screening of colonic polyps can reduce the mortality rate from the cancer. Optical colonoscopy and barium enema are the two most commonly used diagnostic procedures. Other tools include fecal occult blood testing (which detects only 30-40% of colorectal cancer and 10% of adenomas) and sigmoidoscopy (which fails to detect lesions in the proximal colon, where 40% of all cancers occurs, and misses 10-15% sigmoid colon carcinomas [5, 10, 15, 37]). While optical colonoscopy is accurate and can biopsy detected polyps, it is expensive ($1,800), invasive (requires scope insertion), uncomfortable (colon washing and sedation required), time consuming (hours), and carries a small risk of perforation and death (colonic perforation in one in 500 to 1000 cases and death in one in 2,000 to 5,000 cases [29]). It fails to demonstrate the entire colon in 10-15% of the cases and thus misses 10-20% of the lesions [10, 15]. Barium enema is less expensive ($400) and non-invasive, but it is less accurate (less than 78% sensitivity in detecting polyps of size from 5 to 20 mm diameter [28]), more time consuming, and requires a good deal of patient positioning and cooperation when X-ray radiographs of the colon are taken at various views. An accurate, cost-effective, non-invasive, comfortable procedure for mass screening of colonic polyps with a size less than 1 cm in diameter is extremely valuable, since the detection and removal of these small polyps will totally cure the patient. Since 1994, several pilot studies [16, 19, 23, 31, 34, 39] evaluating the feasibility of virtual colonoscopy as an alternative means for colon screening have motivated a great amount of research interests ranging from image formation, and segmentation, to visualization [1, 3, 10, 11, 13, 20, 22, 26, 27, 32, 33, 38]. This alternative means utilizes computer virtual-reality techniques to navigate inside the reconstructed three-dimensional (3D) colon model created from computed tomography (CT) or magnetic resonance (MR) images, looking for polyps. It starts with a bowel cleansing procedure, similar to that used in conventional optical colonoscopy, and is followed by inflating the colon with room air or CO2 gas --- if CT modality is utilized --- introduced through a rectal insert.

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Clinical Chemistry 57:4 Automation and Analytical Techniques Measurement of Hemoglobin A from Filter Papers for David A. Egier,1 Judy L. Keys,1 S. Kim Hall,1 and Matthew J. McQueen1,2,3* BACKGROUND: Stability and transport challenges make standardized protocols, and analyses were performed hemoglobin (Hb) A1c measurement from EDTA whole

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