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El artículo 14 de la nueva Ley Peruana de Arbitraje: Reflexiones sobre el contrato de arbitraje – realidad Eduardo Silva Romero* 1. Quienes elaboran las normas jurídicas deben, en términos generales, mantener un equilibrio (bastante frágil) entre los valores de la flexibilidad (y, por ende, adaptabilidad) del Derecho a situaciones futuras y la previsibilidad del mismo;

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Relationship Between Selective Cyclooxygenase-2 Inhibitors and Acute Myocardial Infarction in Older Adults Daniel H. Solomon, MD, MPH; Sebastian Schneeweiss, MD, ScD; Robert J. Glynn, PhD, ScD; Yuka Kiyota, MD, MPH; Raisa Levin, MSc; Helen Mogun, MSc; Jerry Avorn, MD Background—Although cyclooxygenase-2 inhibitors (coxibs) were developed to cause less gastrointestinal hemorrhage

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Ind. Eng. Chem. Res. 2009, 48, 5590–5597 Synthesis and Controlled Release Properties of Prednisone Intercalated Mg-AlLayered Double Hydroxide Composite Fusu Li,† Lan Jin,† Jingbin Han,† Min Wei,*,† and Congju Li*,‡ State Key Laboratory of Chemical Resource Engineering, Beijing UniVersity of Chemical Technology,Beijing 100029, P. R. China, and College of Material Science and Engineering, Beijing Institute of FashionTechnology, Beijing 100029, P. R. China

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Enriching the Notion of Enculturation: Cognitive Integration, Predictive Processing, and the Case of Reading AcquisitionA Commentary on Richard Menary Many human cognitive capacities are rendered possible by enculturation in com- bination with specific neuronal and bodily dispositions. Acknowledgment of this is of vital importance for a better understanding of the conditions under which soph-

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Skin Infection Manual Franklin Marshall College Skin Infection Manual Table of Contents 1. Introduction1. Herpes Simplex1. Tinea (Ringworm)1. Bacterial Infections (Impetigo, Staphylcoccus, Folliculitis)1. Molluscum Contagiosum The purpose of this manual is to educate people on the various forms of skin infectionsand their treatment. In addition, the NCAA rules and regulations for skin infections inwrestling will be explained.

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La voz de los protagonistas Publicación Oficial de DAECPU Distribución Gratuita Diciembre de 2011 Año 7 Nº 278 Una casa en construcción y de puertas abiertas. / d / José AriSi. 14º Encuentro de Murga Joven / d / Adrián Baseda. Ya están las "reinitas" de Promesas.

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COMPOSANTES BIOLOGIQUES Quelques fondements de biologie moléculaire et de génie génétique intéressants pour approfondir le sujet, malgré le parti pris instructionniste qui sous-tend la présentation. Source : Centre Scientifique de la Biotechnologie/Industrie Canada http://strategis.ic.gc.ca/. Qu'est-ce qu'une cellule ? La cellule est l'unité du monde vivant et les millions de types différents d'organismes qui

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Chairman, R-Texas Report Raises New Questions About Climate Change Assessments ‘It is important to note the isolation of the paleoclimate community; even though they rely heavily on statistical methods they do not seem to be interacting with the statistical community. Additionally, we judge that the sharing of research materials, data and results was haphazardly and grudgingly done. In this case we judge that there was too much reliance on peer review, which was not necessarily independent. Moreover, the work has been sufficiently politicized that this community can hardly reassess their public positions without losing credibility. Overall, our committee believes that Dr. Mann's assessments that the decade of the 1990s was the hottest decade of the millennium and that 1998 was the hottest year of the millennium cannot be supported by his analysis.'

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Revisión de la legislación vigente: MENORES EN CHILE: ¿CUÁNDO SON O NO SON CAPACES?  Mientras un menor puede acceder a anticonceptivos de emergencia sin la autorización ni el conocimiento de sus padres y puede ser considerado responsable penalmente, tienen restricciones para ser contratados hasta los 18 años e incluso se discute si podrían comprar productos "altos en" en sus colegios.

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exploring your options for an unplanned pregnancy W hen faced with an unplanned pregnancy, the decisions you need to make may seem overwhelming. Your emotions are pulling you in different directions, one person is telling you to do this, and someone else is saying don't do that. Perhaps you haven't told anyone. Well, this booklet is designed to help you make the best decision. Find a quiet place

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Islamic Texts: A Source for Acceptance of Queer Individuals into Mainstream Muslim Society Muhsin Hendricks1 Queer2 Muslims face a multitude of challeng- the international queer sector's demand for es, of which one is rejection. This is anchored human rights, has placed pressure on ortho- by the belief that homosexuality is a major sin dox Muslim clergy to defend its religious texts

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Top 10 Global Consumer Trends for 2016 Not to be distributed without permission. TOP 10 GLOBAL CONSUMER TRENDS Daphne Kasriel-Alexander Consumer Trends Consultant © EUROMONITOR INTERNATIONAL 2016 © EUROMONITOR INTERNATIONAL © EUROMONITOR INTERNATIONAL © EUROMONITOR INTERNATIONAL Consumption in 2016 is an interesting blend of established and new trends with

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as at 1 December 2011 Medicines Regulations 1984 David Beattie, Governor-General Order in Council At the Government House at Wellington this 5th day of June 1984 His Excellency the Governor-General in Council Pursuant of the Medicines Act 1981, and, in the caseof the regulations, of that Act, His Excellencythe Governor-General, acting on the advice of the Minister of Healthtendered after consultation with the organisations and bodies that ap-peared to the Minister to be representatives of persons likely to besubstantially affected, and by and with the advice and consent of theExecutive Council, hereby makes the following regulations.

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Chemotherapy for Non-smal Cel Lung Cancer Marianne J. Davies, DNP, CNS-BC, ACNP-BC, AOCNP-BC and Amanda E. Reid, MSN, APRN, ANP-BC Introduction There are several treatment strategies available for non-small cell lung cancer (NSCLC). These include surgery, radiation therapy, chemotherapy, targeted therapy, immunotherapy, and palliative care. Patients may be treated with one type of treatment or a combination of treatments. This

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GREEN MEDICINE: USING LESSONS FROM TORT LAW AND ENVIRONMENTAL LAW TO HOLD PHARMACEUTICAL MANUFACTURERS AND AUTHORIZED DISTRIBUTORS LIABLE FOR INJURIES CAUSED BY COUNTERFEIT DRUGS Stephanie Feldman Aleong* The majority of the American public would be astonished by the frequency with which counterfeit prescription drugs appear on reputable drugstore shelves. In 2004, the Food and Drug Administration (FDA) noted thatthose who counterfeit prescription drugs "deny ill patients the therapies thatcan alleviate suffering and save lives."1 In 2006, the World HealthOrganization (WHO) estimated that there exists a $30 billion market in fakedrugs.2 Although the FDA has tried to characterize the incidence of

High diversity of hepatitis c viral quasispecies is associated with early virological response in patients undergoing antiviral therapy

High Diversity of Hepatitis C Viral Quasispecies Is Associated with Early Virological Response in Patients Undergoing Antiviral Therapy Xiaofeng Fan,1,2 Qing Mao,3,4 Donghui Zhou,1,5 Yang Lu,1 Jianwei Xing,1 Yanjuan Xu,1 Stuart C. Ray,3 and Adrian M. Di Bisceglie1,2 Differential response patterns to optimal antiviral therapy, peginterferon alpha plus ribavi-rin, are well documented in patients with chronic hepatitis C virus (HCV) infection. Amongmany factors that may affect therapeutic efficiency, HCV quasispecies (QS) characteristicshave been a major focus of previous studies, yielding conflicting results. To obtain a com-prehensive understanding of the role of HCV QS in antiviral therapy, we performed thelargest-ever HCV QS analysis in 153 patients infected with HCV genotype 1 strains. A totalof 4,314 viral clones spanning hypervarible region 1 were produced from these patientsduring the first 12 weeks of therapy, followed by detailed genetic analyses. Our data show anexponential distribution pattern of intrapatient QS diversity in this study population inwhich most patients (63%) had small QS diversity with genetic distance (d) less than 0.2. Thegroup of patients with genetic distance located in the decay region (d>0.53) had a signifi-cantly higher early virologic response (EVR) rate (89.5%), which contributed substantiallyto the overall association between EVR and increased baseline QS diversity. In addition, EVRwas linked to a clustered evolutionary pattern in terms of QS dynamic changes. Conclusion:EVR is associated with elevated HCV QS diversity and complexity, especially in patients withsignificantly higher HCV genetic heterogeneity.(HEPATOLOGY 2009;50:1765-1772.)

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UNITED STATES DISTRICT COURT DISTRICT OF NEW JERSEY IN RE SCHERING-PLOUGH Civil Action No. 08-397 (DMC) (JAD) CORPORATION / ENHANCE SECURITIES LITIGATION NOTICE OF PENDENCY OF CLASS ACTION All persons and entities that purchased or acquired Schering-Plough Corporation ("Schering") common stock, 6% mandatory convertible preferred stock maturing August 13, 2010 ("Preferred Stock"), or call options, and/or sold

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3/25/2005 4:38 PM A Prescription for Change: How the Medicare Act Revises Hatch-Waxman to Speed Market Entry of Generic Drugs Stephanie Greene* The Drug Competition and Patent Term Restoration Act of 1984, commonly known as the Hatch-Waxman Act ("Hatch-Waxman" or "Hatch-Waxman Act"), was passed to bring generic drugs to market more quickly. While recognizing the need to maintain incentives for pioneer research and innovation in the pharmaceutical industry, Hatch-Waxman greatly benefits the generic drug industry by providing a method for expedited review and approval of generic products by the Food and Drug Administration (FDA). Although Hatch-Waxman has been successful in substantially increasing generic competition, evidence suggests that manufacturers of brand-name drugs have discovered loopholes in the Act and have engaged in tactics to "game the system" to prolong the life of patents, thereby delaying the market entry of generic competitors. Generic manufacturers have also been accused of abusing provisions of Hatch-Waxman to the detriment of competitors and consumers. Provisions of the Act may tempt generic manufacturers to enter into collusive agreements with brand-name manufacturers. In December of 2003, President Bush signed into law the Medicare Prescription Drug and Modernization Act of 2003. Title XI of the Act amends Hatch-Waxman, in an effort to close loopholes that delay the market entry of generic drugs. The new legislation implements two major changes in the Hatch-Waxman process of generic drug approval and patent challenges. First, the law prevents the innovator drug patentee from filing multiple patents with the FDA, in the hopes of triggering Hatch-Waxman's thirty-month stay provision. When a generic applicant seeks FDA approval of its product and claims that its product will not infringe a patent or that the patent is invalid, an innovator that files a patent infringement suit is granted an automatic thirty-month stay of FDA approval. This provision has enticed innovators to list with the FDA those patents that may not properly claim the drug in question. The improper listing of patents has allowed innovators to stack successive thirty-month stays to delay market entry of generic competition. The new legislation allows an innovator the benefit of only one thirty-month stay per generic applicant per drug. Second, the law prevents collusive agreements between innovator and generic manufacturers as well as such agreements between generic manufacturers that might delay market entry of generic products. The first generic applicant that challenges an innovator's patent and receives FDA approval is entitled to 180 days of market exclusivity under Hatch-Waxman. Subsequent generic applicants may not receive FDA approval for their products until this 180-day exclusivity period has run. New provisions in the law subject agreements that relate to the 180-day exclusivity period to FTC scrutiny. Furthermore, new provisions ensure timely market entry of generic products by specifically enumerating incidents that trigger the

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NIH Public AccessAuthor ManuscriptSens Actuators B Chem. Author manuscript; available in PMC 2013 March 25. NIH-PA Author Manuscript Published in final edited form as: Sens Actuators B Chem. 2011 May 20; 154(1): 22–27. doi:10.1016/j.snb.2010.03.067. A microfluidic platform for electrical detection of DNA M. Javanmard* and R.W. DavisStanford Genome Technology Center, Stanford University, Palo Alto, CA 94304, United States

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NATURAL APPROACHES FOR GASTROESOPHAGEAL REFLUX DISEASE AND RELATED DISORDERS Gastroesophageal reflux disease (GERD) is a chronic recurrent condition affecting millions ofAmericans. A recent study investigating the economic and social burden of gastrointestinal(GI) disease in the United States indicated that GERD was the most common GI-relateddiagnosis given at office visits in 2006. This study also showed that sales of proton pumpinhibitors (PPIs) exceeded $10 billion per year, and the number of prescriptions for PPIs peryear has doubled since 1999.1 Numerous environmental and genetic risk factors have beenimplicated in the pathogenesis of GERD. GERD commonly presents with heartburn and acidregurgitation, although there are numerous atypical presentations, such as chronic cough,noncardiac chest pain, laryngitis, and poor sleep quality. This disease is associated with severalother conditions, including Barrett's esophagus, esophageal carcinoma, gastritis, esophagitis,respiratory conditions, sleep disorders, and various ear-nose-throat (ENT) conditions. Con-ventional treatment often includes the use of PPIs and other acid blockers. Natural therapiesand lifestyle interventions are important to consider, owing to the chronic nature of GERD.

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