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Dentsply.ch

Safety data sheet
according to 1907/2006/EC, Article 31
Printing date 18.03.2016 Version number 9 SECTION 1: Identification of the substance/mixture and of the company/undertaking
· 1.1 Product identifier
· Trade name: AH Plus Paste A
· 1.2 Relevant identified uses of the substance or mixture and uses advised against
· Application of the substance / the mixture root canal filling material
· Uses advised against No further relevant information available.

· 1.3 Details of the supplier of the safety data sheet
· Manufacturer/Supplier:

DENTSPLY DeTrey GmbHDe-Trey-Str. 1D-78467 KonstanzGERMANYTel.: +49-(0)7531-583-0Fax: +49-(0)7531-583-104email: KonstanzDEU.info-sdb@dentsply.com · Further information obtainable from:
- Departement Research & Development for technical information- Departement Marketing & Sales for distribution of the safety data sheets · 1.4 Emergency telephone number: +49-(0)7531-583-0 8:00 - 17:00 (GMT + 1:00)
SECTION 2: Hazards identification
· 2.1 Classification of the substance or mixture
· Classification according to Regulation (EC) No 1272/2008

Skin Irrit. 2 H315 Causes skin irritation. Eye Irrit. 2 H319 Causes serious eye irritation. Skin Sens. 1 H317 May cause an allergic skin reaction. Aquatic Chronic 2 H411 Toxic to aquatic life with long lasting effects. · 2.2 Label elements
· Labelling according to Regulation (EC) No 1272/2008

As this product is a medical device in the meaning of Directive 93/42/EEC and intended for use by the endconsumer and is applied in an invasive manner or body contact, it is exempt from the labelling requirementsaccording to regulation 1272/2008.
The product is classified and labelled according to the CLP regulation.
· Hazard pictograms
· Signal word Warning
· Hazard-determining components of labelling:
· Hazard statements
H315 Causes skin irritation.
H319 Causes serious eye irritation.
H317 May cause an allergic skin reaction.
H411 Toxic to aquatic life with long lasting effects.
· Precautionary statements
Wear protective gloves/protective clothing/eye protection/face protection. Avoid release to the environment. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. (Contd. on page 2) Safety data sheet
according to 1907/2006/EC, Article 31
Printing date 18.03.2016 Version number 9 Trade name: AH Plus Paste A
(Contd. of page 1) Specific treatment (see on this label). Dispose of contents/container in accordance with local/regional/national/internationalregulations. · Additional information:
Contains epoxy constituents. May produce an allergic reaction. · 2.3 Other hazards
· Results of PBT and vPvB assessment
· PBT: Not applicable.
· vPvB: Not applicable.

SECTION 3: Composition/information on ingredients
· 3.2 Chemical characterisation: Mixtures
· Description: Mixture of substances listed below with nonhazardous additions.

· Dangerous components:
CAS: 25068-38-6 Bisphenol A Diglycidylether NLP: 500-033-5 Aquatic Chronic 2, H411; Skin Irrit. 2, H315; Eye Irrit. 2, H319; Skin Sens. 1, H317 CAS: 9003-36-5 Aquatic Chronic 2, H411; Skin Irrit. 2, H315; Eye Irrit. 2, H319; Skin Sens. 1, H317 · Additional information For the wording of the listed hazard phrases refer to section 16.
SECTION 4: First aid measures
· 4.1 Description of first aid measures
· General information No special measures required.
· After inhalation Supply fresh air and to be sure call for a doctor.
· After skin contact Immediately wash with water and soap and rinse thoroughly.
· After eye contact

Rinse opened eye for several minutes under running water. If symptoms persist, consult a doctor. · After swallowing
Rinse out mouth and then drink plenty of water.
If symptoms persist consult doctor.
· 4.2 Most important symptoms and effects, both acute and delayed No further relevant information available.
· Information for doctor No further relevant information available.
· 4.3 Indication of any immediate medical attention and special treatment needed

No further relevant information available. SECTION 5: Firefighting measures
· 5.1 Extinguishing media
· Suitable extinguishing agents

CO2, powder or water spray. Fight larger fires with water spray or alcohol resistant foam. · For safety reasons unsuitable extinguishing agents Water with full jet.
· 5.2 Special hazards arising from the substance or mixture

Formation of toxic gases is possible during heating or in case of fire. · 5.3 Advice for firefighters
· Protective equipment: Self-contained respiratory protective device.

SECTION 6: Accidental release measures
· 6.1 Personal precautions, protective equipment and emergency procedures Wear protective clothing.
(Contd. on page 3) Safety data sheet
according to 1907/2006/EC, Article 31
Printing date 18.03.2016 Version number 9 Trade name: AH Plus Paste A
(Contd. of page 2) · 6.2 Environmental precautions:
Do not allow product to reach sewage system or any water course.
Inform respective authorities in case of seepage into water course or sewage system.
· 6.3 Methods and material for containment and cleaning up:
Absorb with liquid-binding material (sand, diatomite, acid binders, universal binders, sawdust).
Ensure adequate ventilation.
· 6.4 Reference to other sections
See Section 7 for information on safe handlingSee Section 8 for information on personal protection equipment.
See Section 13 for disposal information.
SECTION 7: Handling and storage
· 7.1 Precautions for safe handling
Ensure good ventilation/exhaustion at the workplace.
Prevent formation of aerosols.
Observe normal care for working with chemicals.
· Handling Product is intended for dental use only.
· Information about fire - and explosion protection: No special measures required.

· 7.2 Conditions for safe storage, including any incompatibilities
· Storage
· Requirements to be met by storerooms and receptacles: Store only in the original receptacle.
· Information about storage in one common storage facility: Not required.
· Further information about storage conditions: Store in cool, dry conditions in well sealed receptacles.
· 7.3 Specific end use(s) No further relevant information available.

SECTION 8: Exposure controls/personal protection
· Additional information about design of technical facilities: No further data; see item 7.
· 8.1 Control parameters
· Ingredients with limit values that require monitoring at the workplace:

The product does not contain any relevant quantities of materials with critical values that have to bemonitored at the workplace. · Additional information: The lists valid during the making were used as basis.
· 8.2 Exposure controls
· Personal protective equipment
· General protective and hygienic measures

Keep away from foodstuffs, beverages and feed.
Immediately remove all soiled and contaminated clothingWash hands before breaks and at the end of work.
Avoid contact with the eyes and skin.
· Respiratory protection: Not necessary if room is well-ventilated.
· Protection of hands:

The glove material has to be impermeable and resistant to the product/ the substance/ the preparation.
Selection of the glove material on consideration of the penetration times, rates of diffusion and thedegradation
· Material of gloves
Nitrile rubber, NBRRecommended thickness of the material: 0.38 mmThe selection of the suitable gloves does not only depend on the material, but also on further marks of qualityand varies from manufacturer to manufacturer. As the product is a preparation of several substances, the (Contd. on page 4) Safety data sheet
according to 1907/2006/EC, Article 31
Printing date 18.03.2016 Version number 9 Trade name: AH Plus Paste A
(Contd. of page 3) resistance of the glove material can not be calculated in advance and has therefore to be checked prior to theapplication. · Penetration time of glove material
Value for the permeation: Level 3The exact break trough time has to be found out by the manufacturer of the protective gloves and has to beobserved. · Eye protection:
Tightly sealed goggles. · Body protection: Protective work clothing.
SECTION 9: Physical and chemical properties
· 9.1 Information on basic physical and chemical properties
· General Information
· Appearance:

· Odour threshold:
Not determined. Not determined. · Change in condition
Melting point/Melting range:
Boiling point/Boiling range:
· Flash point:
Not applicable · Flammability (solid, gaseous)
Not applicable. · Ignition temperature:
Not applicable · Decomposition temperature:
Not determined. Product is not selfigniting. · Danger of explosion:
Product does not present an explosion hazard. · Explosion limits:
Not determined. Not determined. · Vapour pressure:
Not determined. Not determined · Relative density
Not determined. · Vapour density
Not determined. · Evaporation rate
Not determined. · Solubility in / Miscibility with
Not miscible or difficult to mix · Partition coefficient (n-octanol/water): Not determined.
Not determined. Not determined. · Solvent content:
(Contd. on page 5) Safety data sheet
according to 1907/2006/EC, Article 31
Printing date 18.03.2016 Version number 9 Trade name: AH Plus Paste A
(Contd. of page 4) · 9.2 Other information
No further relevant information available. SECTION 10: Stability and reactivity
· 10.1 Reactivity No further relevant information available.
· 10.2 Chemical stability
· Thermal decomposition / conditions to be avoided: No decomposition if used according to specifications.
· 10.3 Possibility of hazardous reactions No dangerous reactions known
· 10.4 Conditions to avoid No further relevant information available.
· 10.5 Incompatible materials: No further relevant information available.
· 10.6 Hazardous decomposition products: No dangerous decomposition products known

SECTION 11: Toxicological information
· 11.1 Information on toxicological effects
· Acute toxicity Based on available data, the classification criteria are not met.

· LD/LC50 values relevant for classification:
CAS: 25068-38-6 Bisphenol A Diglycidylether
LD50 >5000 mg/kg (rat) Dermal LD50 >2000 mg/kg (rabbit) LD50 > 5000 mg/kg (rat) · Primary irritant effect:
· Skin corrosion/irritation

Causes skin irritation. · Serious eye damage/irritation
Causes serious eye irritation. · Respiratory or skin sensitisation
May cause an allergic skin reaction. · CMR effects (carcinogenity, mutagenicity and toxicity for reproduction)
· Germ cell mutagenicity Based on available data, the classification criteria are not met.
· Carcinogenicity Based on available data, the classification criteria are not met.
· Reproductive toxicity Based on available data, the classification criteria are not met.
· STOT-single exposure Based on available data, the classification criteria are not met.
· STOT-repeated exposure Based on available data, the classification criteria are not met.
· Aspiration hazard Based on available data, the classification criteria are not met.

SECTION 12: Ecological information
· 12.1 Toxicity
· Aquatic toxicity:
CAS: 25068-38-6 Bisphenol A Diglycidylether
LC50/96h 1.5 mg/l (Fish acute toxicity study) EC50/24h 3.6 mg/L (daphnia magna) LC50/96h 2 mg/l (Fish acute toxicity study) EC50/24h 2 mg/L (daphnia magna) · 12.2 Persistence and degradability No further relevant information available.
· 12.3 Bioaccumulative potential No further relevant information available.
· 12.4 Mobility in soil No further relevant information available.

(Contd. on page 6) Safety data sheet
according to 1907/2006/EC, Article 31
Printing date 18.03.2016 Version number 9 Trade name: AH Plus Paste A
(Contd. of page 5) · Ecotoxical effects:
· Remark:

Toxic for water fleasToxic for fish · Additional ecological information:
· General notes:

Do not allow product to reach ground water, water course or sewage system.
Danger to drinking water if even small quantities leak into the ground.
Also poisonous for fish and plankton in water bodies.
Toxic for aquatic organisms
· 12.5 Results of PBT and vPvB assessment
· PBT: Not applicable.
· vPvB: Not applicable.
· 12.6 Other adverse effects No further relevant information available.

SECTION 13: Disposal considerations
· 13.1 Waste treatment methods
· Recommendation

Must not be disposed together with household garbage. Do not allow product to reach sewagesystem. · European waste catalogue
18 01 06* chemicals consisting of or containing hazardous substances Irritant - skin irritation and eye damage · Uncleaned packaging:
· Recommendation: Disposal must be made according to official regulations.

SECTION 14: Transport information
· 14.1 UN-Number
· ADR, IMDG, IATA

· 14.2 UN proper shipping name
· ADR

3082 ENVIRONMENTALLY HAZARDOUS SUBSTANCE,LIQUID, N.O.S. (reaction product: bisphenol-A-(epichlorhydrin) epoxy resin (number average molecularweight = 700), Bis-[4-(-2,3-epoxypropoxy)phenyl]-methane) ENVIRONMENTALLY HAZARDOUS SUBSTANCE,LIQUID, N.O.S. (reaction product: bisphenol-A-(epichlorhydrin) epoxy resin (number average molecularweight = 700), Bis-[4-(-2.3-epoxypropoxy)phenyl]-methane), MARINE POLLUTANT Environmentally hazardous substance, liquid, n.o.s.
(reaction product: bisphenol-A-(epichlorhydrin) epoxyresin (number average molecular weight = 700), Bis-[4-(-2.3-epoxypropoxy)phenyl]-methane)
(Contd. on page 7) Safety data sheet
according to 1907/2006/EC, Article 31
Printing date 18.03.2016 Version number 9 Trade name: AH Plus Paste A
(Contd. of page 6) · 14.3 Transport hazard class(es)
9 (M6) Miscellaneous dangerous substances and articles. · IMDG, IATA
9 Miscellaneous dangerous substances and articles. · 14.4 Packing group
· ADR, IMDG, IATA

· 14.5 Environmental hazards:
Product contains environmentally hazardous substances:reaction product: bisphenol-A-(epichlorhydrin) epoxyresin (number average molecular weight = 700) · Marine pollutant:
Symbol (fish and tree) · Special marking (ADR):
Symbol (fish and tree) · Special marking (IATA):
Symbol (fish and tree) · 14.6 Special precautions for user
Warning: Miscellaneous dangerous substances andarticles. · Danger code (Kemler):
· EMS Number:
· Stowage Category
· 14.7 Transport in bulk according to Annex II of
Marpol and the IBC Code
Not applicable. · ADR
· Limited quantities (LQ)

· Excepted quantities (EQ)
Code: E1Maximum net quantity per inner packaging: 30 mlMaximum net quantity per outer packaging: 1000 ml · Transport category
· Tunnel restriction code
Exemption according to ADR special provision 375:This substance is not subject to the other provisions of theADR if packed in net quantities of 5L or 5kg per individualor inner packaging, provided that sub-sections 4.1.1.1,4.1.1.2 and 4.1.1.4 to 4.1.1.8 are complied with. · IMDG
· Limited quantities (LQ)

· Excepted quantities (EQ)
Code: E1Maximum net quantity per inner packaging: 30 mlMaximum net quantity per outer packaging: 1000 ml · UN "Model Regulation":
U N 3 0 8 2 , E N V I R O N M E N T A L L Y H A Z A R D O U SSUBSTANCE, LIQUID, N.O.S. (reaction product:bisphenol-A-(epichlorhydrin) epoxy resin (number averagemolecular weight = 700), Bis-[4-(-2,3-epoxypropoxy) (Contd. on page 8) Safety data sheet
according to 1907/2006/EC, Article 31
Printing date 18.03.2016 Version number 9 Trade name: AH Plus Paste A
(Contd. of page 7) phenyl]-methane), 9, III SECTION 15: Regulatory information
· 15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
· Directive 2012/18/EU
· Named dangerous substances - ANNEX I None of the ingredients is listed.
· Seveso category E2 Hazardous to the Aquatic Environment
· Qualifying quantity (tonnes) for the application of lower-tier requirements 200 t
· Qualifying quantity (tonnes) for the application of upper-tier requirements 500 t
· 15.2 Chemical safety assessment: A Chemical Safety Assessment has not been carried out.

SECTION 16: Other information
This information is based on our present knowledge. However, this shall not constitute a guarantee for anyspecific product features and shall not establish a legally valid contractual relationship. The attached safety data sheet covers the dangers and measures to be taken when large quantities of materialare released, for example due to accidents during transport or storage by the dealer.
For quantities of material typically used in clinical practice, information necessary for safe use and storageof the product is given in the DFU.
· Relevant phrases
H315 Causes skin irritation.
H317 May cause an allergic skin reaction.
H319 Causes serious eye irritation.
H411 Toxic to aquatic life with long lasting effects.
· Department issuing SDS: Research & Development
· Contact: HotLine for urgent technical support: +49-7531-583-350
· Abbreviations and acronyms:

ADR: Accord européen sur le transport des marchandises dangereuses par Route (European Agreement concerning the InternationalCarriage of Dangerous Goods by Road)IMDG: International Maritime Code for Dangerous GoodsIATA: International Air Transport AssociationGHS: Globally Harmonised System of Classification and Labelling of ChemicalsEINECS: European Inventory of Existing Commercial Chemical SubstancesELINCS: European List of Notified Chemical SubstancesCAS: Chemical Abstracts Service (division of the American Chemical Society)LC50: Lethal concentration, 50 percentLD50: Lethal dose, 50 percentPBT: Persistent, Bioaccumulative and ToxicvPvB: very Persistent and very BioaccumulativeSkin Irrit. 2: Skin corrosion/irritation, Hazard Category 2Eye Irrit. 2: Serious eye damage/eye irritation, Hazard Category 2Skin Sens. 1: Sensitisation - Skin, Hazard Category 1Aquatic Chronic 2: Hazardous to the aquatic environment - Chronic Hazard, Category 2 · * Data compared to the previous version altered.
Safety data sheet
according to 1907/2006/EC, Article 31
Printing date 18.03.2016 Version number 8 SECTION 1: Identification of the substance/mixture and of the company/undertaking
· 1.1 Product identifier
· Trade name: AH Plus Paste B
· 1.2 Relevant identified uses of the substance or mixture and uses advised against
· Application of the substance / the mixture root canal filling material
· Uses advised against No further relevant information available.

· 1.3 Details of the supplier of the safety data sheet
· Manufacturer/Supplier:

DENTSPLY DeTrey GmbHDe-Trey-Str. 1D-78467 KonstanzGERMANYTel.: +49-(0)7531-583-0Fax: +49-(0)7531-583-104email: KonstanzDEU.info-sdb@dentsply.com · Further information obtainable from:
- Departement Research & Development for technical information- Departement Marketing & Sales for distribution of the safety data sheets · 1.4 Emergency telephone number: +49-(0)7531-583-0 8:00 - 17:00 (GMT + 1:00)
SECTION 2: Hazards identification
· 2.1 Classification of the substance or mixture
· Classification according to Regulation (EC) No 1272/2008

Skin Irrit. 2 H315 Causes skin irritation. Eye Irrit. 2 H319 Causes serious eye irritation. · 2.2 Label elements
· Labelling according to Regulation (EC) No 1272/2008

As this product is a medical device in the meaning of Directive 93/42/EEC and intended for use by the endconsumer and is applied in an invasive manner or body contact, it is exempt from the labelling requirementsaccording to regulation 1272/2008.
The product is classified and labelled according to the CLP regulation.
· Hazard pictograms
· Signal word Warning
· Hazard statements

H315 Causes skin irritation.
H319 Causes serious eye irritation.
· Precautionary statements
Wear protective gloves/protective clothing/eye protection/face protection. Wash thoroughly after handling. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Specific treatment (see on this label). If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Get medical advice/attention. · Additional information:
Contains Octahydro-4,7-methano-1H-indendimethylamin. May produce an allergic reaction. · 2.3 Other hazards
· Results of PBT and vPvB assessment
· PBT: Not applicable.

(Contd. on page 2) Safety data sheet
according to 1907/2006/EC, Article 31
Printing date 18.03.2016 Version number 8 Trade name: AH Plus Paste B
(Contd. of page 1) · vPvB: Not applicable.
SECTION 3: Composition/information on ingredients
· 3.2 Chemical characterisation: Mixtures
· Description: Mixture of substances listed below with nonhazardous additions.

· Dangerous components:
CAS: 113506-22-2 Acute Tox. 4, H302; Skin Irrit. 2, H315; Eye Irrit. 2, H319; STOT SE 3, CAS: 768-94-5 EINECS: 212-201-2 Acute Tox. 4, H302; Skin Irrit. 2, H315; Eye Irrit. 2, H319; STOT SE 3, CAS: 68889-71-4 Acute Tox. 3, H311; Skin Corr. 1B, H314; Acute Tox. 4, H302; Skin Sens. 1, H317 · Additional information For the wording of the listed hazard phrases refer to section 16.
SECTION 4: First aid measures
· 4.1 Description of first aid measures
· General information No special measures required.
· After inhalation Supply fresh air; consult doctor in case of complaints.
· After skin contact Immediately wash with water and soap and rinse thoroughly.
· After eye contact Rinse opened eye for several minutes under running water.
· After swallowing

Rinse out mouth and then drink plenty of water.
Seek medical treatment.
· 4.2 Most important symptoms and effects, both acute and delayed No further relevant information available.
· Information for doctor No further relevant information available.
· 4.3 Indication of any immediate medical attention and special treatment needed

No further relevant information available. SECTION 5: Firefighting measures
· 5.1 Extinguishing media
· Suitable extinguishing agents

CO2, powder or water spray. Fight larger fires with water spray or alcohol resistant foam. · For safety reasons unsuitable extinguishing agents Water with full jet.
· 5.2 Special hazards arising from the substance or mixture

Formation of toxic gases is possible during heating or in case of fire. · 5.3 Advice for firefighters
· Protective equipment: Self-contained respiratory protective device.

SECTION 6: Accidental release measures
· 6.1 Personal precautions, protective equipment and emergency procedures
Wear protective equipment. Keep unprotected persons away. · 6.2 Environmental precautions: Do not allow to enter sewers/ surface or ground water.
· 6.3 Methods and material for containment and cleaning up:

Absorb with liquid-binding material (sand, diatomite, acid binders, universal binders, sawdust). · 6.4 Reference to other sections
No dangerous substances are released.
See Section 7 for information on safe handling
(Contd. on page 3) Safety data sheet
according to 1907/2006/EC, Article 31
Printing date 18.03.2016 Version number 8 Trade name: AH Plus Paste B
(Contd. of page 2) See Section 8 for information on personal protection equipment.
See Section 13 for disposal information.
SECTION 7: Handling and storage
· 7.1 Precautions for safe handling Observe normal care for working with chemicals.
· Handling Product is intended for dental use only.
· Information about fire - and explosion protection: No special measures required.

· 7.2 Conditions for safe storage, including any incompatibilities
· Storage
· Requirements to be met by storerooms and receptacles: Store only in the original receptacle.
· Information about storage in one common storage facility: Not required.
· Further information about storage conditions: Store in cool, dry conditions in well sealed receptacles.
· 7.3 Specific end use(s) No further relevant information available.

SECTION 8: Exposure controls/personal protection
· Additional information about design of technical facilities: No further data; see item 7.
· 8.1 Control parameters
· Ingredients with limit values that require monitoring at the workplace:

The product does not contain any relevant quantities of materials with critical values that have to bemonitored at the workplace. · Additional information: The lists valid during the making were used as basis.
· 8.2 Exposure controls
· Personal protective equipment
· General protective and hygienic measures Wash hands before breaks and at the end of work.
· Respiratory protection: Not necessary if room is well-ventilated.
· Protection of hands:

The glove material has to be impermeable and resistant to the product/ the substance/ the preparation.
Due to missing tests no recommendation to the glove material can be given for the product/ the preparation/the chemical mixture.
Selection of the glove material on consideration of the penetration times, rates of diffusion and thedegradation
· Material of gloves
The selection of the suitable gloves does not only depend on the material, but also on further marks of qualityand varies from manufacturer to manufacturer. As the product is a preparation of several substances, theresistance of the glove material can not be calculated in advance and has therefore to be checked prior to theapplication. · Penetration time of glove material
The exact break trough time has to be found out by the manufacturer of the protective gloves and has to beobserved. · Eye protection: Safety glasses
· Body protection: Protective work clothing.

(Contd. on page 4) Safety data sheet
according to 1907/2006/EC, Article 31
Printing date 18.03.2016 Version number 8 Trade name: AH Plus Paste B
(Contd. of page 3) SECTION 9: Physical and chemical properties
· 9.1 Information on basic physical and chemical properties
· General Information
· Appearance:

· Odour threshold:
Not determined. Not determined. · Change in condition
Melting point/Melting range:
Boiling point/Boiling range:
· Flash point:
Not applicable · Flammability (solid, gaseous)
Not applicable. · Ignition temperature:
Not applicable · Decomposition temperature:
Not determined. Product is not selfigniting. · Danger of explosion:
Product does not present an explosion hazard. · Explosion limits:
Not determined. Not determined. · Vapour pressure:
Not determined. Not determined · Relative density
Not determined. · Vapour density
Not determined. · Evaporation rate
Not determined. · Solubility in / Miscibility with
Not miscible or difficult to mix · Partition coefficient (n-octanol/water): Not determined.
Not determined. Not determined. · Solvent content:
· 9.2 Other information
No further relevant information available. SECTION 10: Stability and reactivity
· 10.1 Reactivity No further relevant information available.
· 10.2 Chemical stability
· Thermal decomposition / conditions to be avoided: No decomposition if used according to specifications.
· 10.3 Possibility of hazardous reactions No dangerous reactions known
· 10.4 Conditions to avoid No further relevant information available.
· 10.5 Incompatible materials: No further relevant information available.
· 10.6 Hazardous decomposition products: Irritant gases/vapours

(Contd. on page 5) Safety data sheet
according to 1907/2006/EC, Article 31
Printing date 18.03.2016 Version number 8 Trade name: AH Plus Paste B
(Contd. of page 4) SECTION 11: Toxicological information
· 11.1 Information on toxicological effects
· Acute toxicity Based on available data, the classification criteria are not met.

· LD/LC50 values relevant for classification:
ATE (Acute Toxicity Estimates)
LD50 3381 mg/kg (rat) Dermal LD50 66667 mg/kg (rat) LD50 458 mg/kg (rat) CAS: 768-94-5 amantadine
LD50 900 mg/kg (rat) LD50 502 mg/kg (rat) Dermal LD50 400-500 mg/kg (rat) · Primary irritant effect:
· Skin corrosion/irritation

Causes skin irritation. · Serious eye damage/irritation
Causes serious eye irritation. · Respiratory or skin sensitisation Based on available data, the classification criteria are not met.
· CMR effects (carcinogenity, mutagenicity and toxicity for reproduction)
· Germ cell mutagenicity Based on available data, the classification criteria are not met.
· Carcinogenicity Based on available data, the classification criteria are not met.
· Reproductive toxicity Based on available data, the classification criteria are not met.
· STOT-single exposure Based on available data, the classification criteria are not met.
· STOT-repeated exposure Based on available data, the classification criteria are not met.
· Aspiration hazard Based on available data, the classification criteria are not met.

SECTION 12: Ecological information
· 12.1 Toxicity
· Aquatic toxicity:
CAS: 768-94-5 amantadine
LC50/96h 25 mg/l (Fish acute toxicity study) EC50/48h 22.1 mg/L (daphnia magna) LC50/96h 125 mg/l (Fish acute toxicity study) · 12.2 Persistence and degradability No further relevant information available.
· 12.3 Bioaccumulative potential No further relevant information available.
· 12.4 Mobility in soil No further relevant information available.
· Additional ecological information:
· General notes:

Do not allow undiluted product or large quantities of it to reach ground water, water course or sewagesystem. · 12.5 Results of PBT and vPvB assessment
· PBT: Not applicable.
· vPvB: Not applicable.
· 12.6 Other adverse effects No further relevant information available.

(Contd. on page 6) Safety data sheet
according to 1907/2006/EC, Article 31
Printing date 18.03.2016 Version number 8 Trade name: AH Plus Paste B
(Contd. of page 5) SECTION 13: Disposal considerations
· 13.1 Waste treatment methods
· Recommendation

Must not be disposed together with household garbage. Do not allow product to reach sewagesystem. · European waste catalogue
18 01 06* chemicals consisting of or containing dangerous substances · Uncleaned packaging:
· Recommendation: Disposal must be made according to official regulations.

SECTION 14: Transport information
· 14.1 UN-Number
· ADR, ADN, IMDG, IATA

· 14.2 UN proper shipping name
· ADR

· ADN, IMDG, IATA
· 14.3 Transport hazard class(es)
· ADR, ADN, IMDG, IATA
· Class

· 14.4 Packing group
· ADR, IMDG, IATA

· 14.5 Environmental hazards:
· Marine pollutant:

· 14.6 Special precautions for user
Not applicable. · 14.7 Transport in bulk according to Annex II of
Marpol and the IBC Code
Not applicable. · UN "Model Regulation":
SECTION 15: Regulatory information
· 15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
No further relevant information available. · 15.2 Chemical safety assessment: A Chemical Safety Assessment has not been carried out.
SECTION 16: Other information
This information is based on our present knowledge. However, this shall not constitute a guarantee for anyspecific product features and shall not establish a legally valid contractual relationship. The attached safety data sheet covers the dangers and measures to be taken when large quantities of materialare released, for example due to accidents during transport or storage by the dealer.
For quantities of material typically used in clinical practice, information necessary for safe use and storageof the product is given in the DFU.
· Relevant phrases
H302 Harmful if swallowed. (Contd. on page 7) Safety data sheet
according to 1907/2006/EC, Article 31
Printing date 18.03.2016 Version number 8 Trade name: AH Plus Paste B
(Contd. of page 6) H311 Toxic in contact with skin.
H314 Causes severe skin burns and eye damage.
H315 Causes skin irritation.
H317 May cause an allergic skin reaction.
H319 Causes serious eye irritation.
H335 May cause respiratory irritation.
· Department issuing SDS: Research & Development
· Contact: HotLine for urgent technical support: +49-7531-583-350
· Abbreviations and acronyms:

ADR: Accord européen sur le transport des marchandises dangereuses par Route (European Agreement concerning the InternationalCarriage of Dangerous Goods by Road)IMDG: International Maritime Code for Dangerous GoodsIATA: International Air Transport AssociationGHS: Globally Harmonised System of Classification and Labelling of ChemicalsEINECS: European Inventory of Existing Commercial Chemical SubstancesELINCS: European List of Notified Chemical SubstancesCAS: Chemical Abstracts Service (division of the American Chemical Society)LC50: Lethal concentration, 50 percentLD50: Lethal dose, 50 percentPBT: Persistent, Bioaccumulative and ToxicvPvB: very Persistent and very BioaccumulativeAcute Tox. 4: Acute toxicity, Hazard Category 4Acute Tox. 3: Acute toxicity, Hazard Category 3Skin Corr. 1B: Skin corrosion/irritation, Hazard Category 1BSkin Irrit. 2: Skin corrosion/irritation, Hazard Category 2Eye Irrit. 2: Serious eye damage/eye irritation, Hazard Category 2Skin Sens. 1: Sensitisation - Skin, Hazard Category 1STOT SE 3: Specific target organ toxicity - Single exposure, Hazard Category 3 · * Data compared to the previous version altered.

Source: http://www.dentsply.ch/docs/msds/sd206_-_AH_Plus_(GB).pdf

Microsoft word - hypothermia in nuerosurgical patients

Diagnosis and Management of Hypothermia in Neurosurgical Patients By Avery Jackson, MD Dear Colleagues: I came across an article that I wanted to share with you that was put together by Powers and Friedman out of Duke University Department of Neurosurgery regarding hyponatremia. It is in Contemporary Neurosurgery. I found it to be extremely helpful in the management of hyponatremia. Hyponatremia is a common complication of subarachnoid hemorrhage, brain tumors and cerebral infections. Hormonal factor such as Natriuretic Peptides and Antidiuretic Hormone play important roles in hyponatremia and neurosurgical patients. It is important to differentiate between cerebral salt-wasting (CSW) and syndrome of inappropriate secretion of antidiuretic hormone (SIADH).

Bovine gb 300 dpi.pdf

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