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(888) 694-8381 GenOne™ Spray
GenOne is a gentamicin sulfate with betamethasone valerate topical spray that is indicated for the treatment in dogs of
infected superficial lesions for bacteria sensitive to gentamicin. Each milliliter contains gentamicin sulfate equivalent to
0.57 mg gentamicin base, and betamethasone valerate equivalent to 0.284 mg betamethasone. Gentamicin, a broad-
spectrum antibiotic, is a highly effective topical treatment for bacterial infections of the skin. Betamethasone valerate, a
synthetic glucocorticoid, has been shown to provide anti-inflammatory and antipruritic activity in the topical management of
corticosteroid-responsive infected superficial lesions in dogs. For topical use in dogs only. Prescription.
ITEM# DESCRIPTION SIZE501007 GenOne Spray 502007 GenOne Spray 503007 GenOne Spray Veterinarians can purchase VetOne® products exclusively through MWI Veterinary Supply or AAHA MARKETLink.
the right choice.
(888) 694-8381 WARNING: Clinical and experimental data
may result in inhibition of endogenous steroid produc- have demonstrated that corticosteroids tion following drug withdrawal.
administered orally or parenterally to animals may induce the first stage of par- In patients presently receiving or recently withdrawn turition when administered during the last from systemic corticosteroid treatments, therapy with (Gentamicin Sulfate with Betamethasone Valerate) trimester of pregnancy and may precipitate a rapidly acting corticosteroid should be considered in premature parturition followed by dystocia, especially stressful situations.
fetal death, retained placenta, and metritis.
If ingestion should occur, patients should be closely Additionally, corticosteroids administered to observed for the usual signs of adrenocorticoid over- dogs, rabbits and rodents during preg- dosage, which include sodium retention, potassium nancy have produced cleft palate. Other loss, fluid retention, weight gains, polydipsia, and/or GENTAMICIN SULFATE WITH BETAMETHASONE congenital anomalies including deformed polyuria. Prolonged use or overdosage may produce VALERATE TOPICAL SPRAY forelegs, phocomelia, and anasarca have adverse immunosuppressive effects.
been reported in offspring of dogs which ANADA #200-188, Approved by FDA.
received corticosteroids during pregnancy.
HOW SUPPLIED: Plastic spray bottle containing 60
mL, 120 mL or 240 mL of GenOne™ Spray.
For Topical Use in Dogs Only INDICATIONS: For the treatment of infected super-
ficial lesions in dogs caused by bacteria sensitive to
Store upright between 2° and 30°C (36°F and 86°F).
CAUTION: Federal law restricts this drug to use by or
on the order of a licensed veterinarian.
CONTRAINDICATIONS: If hypersensitivity to any of the
1. Hennessy PW, et al. In vitro activity of gentamicin DESCRIPTION: Each mL contains: gentamicin sulfate
components occurs, treatment with this product should against bacteria isolated from domestic animals. equivalent to 0.57 mg gentamicin base, betametha- be discontinued and appropriate therapy instituted.
Veterinary Medicine/Small Animal Clinician. November sone valerate equivalent to 0.284 mg betametha- sone,163 mg isopropyl alcohol, propylene glycol, DOSAGE AND ADMINISTRATION: Prior to treatment,
2. Bachmann HJ, et al. Comparative in vitro activity methylparaben and propylparaben as preservatives, remove excessive hair and clean the lesion and adja- of gentamicin and other antibiotics against bacteria purified water q.s. Hydrochloric acid may be added cent area. Hold bottle upright 3 to 6 inches from the isolated from clinical samples from dogs, cats, horses to adjust pH.
lesion and depress the sprayer head twice. Administer and cattle. Veterinary Medicine/Small Animal Clinician. 2 to 4 times daily for 7 days.
October 1975; 1218-1222 CHEMISTRY: Gentamicin is a mixture of aminogly-
2. McKenzie, HW., Atkinson, RM.: Topical activities coside antibiotics derived from the fermentation of Each depression of the sprayer head delivers 0.7 mL of of betamethasone esters in man. Arch Derm. 1964; Micromonospora purpurea. Gentamicin sulfate is a GenOne™ Spray.
mixture of sulfate salts of the antibiotics produced in this fermentation. The salts are weakly acidic and TOXICITY: GenOne™ Spray was well tolerated in
freely soluble in water.
an abraded skin study in dogs. No treatment-related MWI Veterinary Supply toxicological changes in the skin were observed.
Gentamicin sulfate contains not less than 500 micro- grams of gentamicin base per milligram.
Systemic effects directly related to treatment were confined to histological changes in the adrenals, liver, Betamethasone valerate is a synthetic glucocorticoid.
and kidney and to organ-to-body weight ratios of adrenals. All were dose related, were typical for or PHARMACOLOGY: Gentamicin, a broad-spectrum
not unexpected with corticosteroid therapy, and were antibiotic, is a highly effective topical treatment for considered reversible with cessation of treatment.
bacterial infections of the skin. In vitro, gentamicin is bactericidal against a wide variety of gram-positive SIDE EFFECTS: Side effects such as SAP and SGPT
and gram-negative bacteria isolated from domestic enzyme elevations, weight loss, anorexia, polydipsia, animals.1, 2 Specifically, gentamicin is active against and polyuria have occurred following parenteral or the following organisms isolated from canine skin: systemic use of synthetic corticosteroids in dogs. Alcaligenes sp., Citrobacter sp., Klebsiella sp., Vomiting and diarrhea (occasionally bloody) have been Pseudomonas aeruginosa, indole-positive and nega- observed in dogs.
tive Proteus sp., Escherichia coli, Enterobacter sp., Staphylococcus sp., and Streptococcus sp.
Cushing's syndrome in dogs has been reported in as-sociation with prolonged or repeated steroid therapy.
Betamethasone valerate emerged from intensive research as the most promising of some 50 newly PRECAUTIONS: Antibiotic susceptibility of the patho-
synthesized corticosteroids in the experimental model genic organism(s) should be determined prior to the described by McKenzie3, et al. This human bioassay use of this preparation. Use of topical antibiotics may technique has been found reliable for evaluating the permit overgrowth of non-susceptible bacteria, fungi, vasoconstrictor properties of new topical corticoste- or yeasts. If this occurs, treatment should be instituted roids and is useful in predicting clinical efficacy.
with other appropriate agents as indicated.
Betamethasone valerate in veterinary medicine Administration of recommended dose beyond 7 days has been shown to provide anti-inflammatory and may result in delayed wound healing. Animals treated antipruritic activity in the topical management of longer than 7 days should be monitored closely.
corticosteroid-responsive infected superficial lesions in dogs.
Avoid ingestion. Oral or parenteral use of corticoste-roids, depending on dose, duration, and specific steroid


Guidelines for the management of the infant with neonatal abstinence syndrome (nas)

GUIDELINES FOR THE MANAGEMENT OF THE INFANT WITH NEONATAL ABSTINENCE SYNDROME Background Neonatal Abstinence Syndrome (NAS) is a syndrome of drug withdrawal observed in infants of mothers physically dependent on drugs. Also known as neonatal withdrawal syndrome or passive addiction, NAS is a condition resulting from exposure in utero or postnatal exposure to opioids and other illicit drugs. It is more common in infants born to opioid-dependent women than in infants born to women dependent on other drugs or alcohol.1

Chapter 24 Periprosthetic InfectionFollowing Total Knee Arthroplasty Michael Soudry, Arnan Greental,Gabriel Nierenberg, Mazen Falah andNahum Rosenberg Additional information is available at the end of the chapter One of the most devastating complications of prosthetic knee arthroplasty is a periprosthetic infection. This complication occurs in 1-2% of knee arthroplasties [1,2] and can exceed 4% in