Case reports of Acne with long
lasting follow up.
Chatzimanuil A. DDS Secretary Dernikou M.F. MD, MSc Homeopathy. Tsilikas A.MD, Dermatologist, MSc Homeopathy,board member Michalakis M. DDS, MSc, specialist in Oral Diagnostics&Radiology,President.

Some think of acne as a modern phenomenon. The word "aku-t" occurs in the Ebers Papyrus 6
But quite the contrary, ancient people wrote of and elsewhere and is translated 5 as "boils, acne as soon as they could write at all. Ancient blains, sores, pustules, any inflamed swelling". Egyptian writings mention how Pharoahs
Τhe meaning of the Greek word "ΑΚΜΗ " is
struggled with the disease. Traces of an important. Previous to the second century A.D. essential oil used in the treatment of acne scars it had a definite medical meaning, to which were found in King Tut's tomb. Galen5 devotes a whole paragraph, as "the The ancient Greek physicians certainly height of a disease", "the crisis of a fever",.and recognized acne which they knew as ΙΟΝΘΟΙ, a
is not in any way related to skin disease. condition which Aristotle1 describes in sufficient However, in the second century A.D. It s detail for there to be little doubt of the meaning appears to be widened to include the identification. Hippocrates2 also uses the term, height or culmination of growth and peak
but does not state .what he means by it, development and thus "puberty". It is in this
although his wording suggests that it was a well- meaning that it first appears in relation to known and recognized disease. That Acne were
«ΙΟΝΘΟΙ" in the works of the Greek physician associated with puberty is implied in the
Julius Pollux. The Latin text is not infrequently meaning of this word in the singular, ΙΟΝΘΟΣ, quoted in later literature but the Greek text which means "the first growth of the beard".
seems more significant philologically The early Roman physicians, on the other hand,
used the word "varus" which is mentioned by
Pliny3 and discussed briefly by Celsus4.

blackheads (comedones), inflamed pustules and papules (pimples) and whiteheads (closed comedones). Acne vulgaris usually affects the face but can show up on the ears, neck, chest and back. This occurs
because these areas contain more sebaceous glands than other areas of the body.
• Is a chronic inflammatory disease • Appears most common in adolescence especially and around it. • It affects about 80% of persons in this age group. • Can be accompanied with various skin problems of early and late youth mostly related to the level of variability in hormones primary androgens.
Particular acne is of multifactorial pathogenesis: • Androgens stimulate hyper the skin represents the outer lever of
production of sebum the human core (where probably the vital force exists9) but as an organ it • excessive sebum blocks the
seems to affect greatly future pilosebaceous units which are resistance to physical and psychic
hyper-keratinized and infected stress of a human being. with Propionibacterium acnes.
Unfortunately this chronic • Excess Uptake in carbohydrates inflammatory disease affects greatly aggravates the clinical picture the teenager image to society & self confidence, boosting stress further . • Is certainly stress related Current Acne treatments:
Systemic :
Chemical peelings :
Minocycline Scrubs Abrasive pads and cloths Phototherapy: 10can be used to treat mild to
moderate acne only
Benzoyl Peroxide When porphyrins are exposed to wavelength azelaic acid blue-violet light from 405 to 420 nanometers,
oxygen is separated from the porphyrin
retinoic acid (tretinoin, molecule producing free radicals which kills the
adapalene,tazarotene) RED Light Therapy 655nm-665nm exhibits Anti-
birth control pills (females) Inflammatory Action – reduces the redness and inflammation associated with acne lesions. Promotes wound healing and tissue growth – this action is beneficial for acne scars which is common with moderate and severe acne. 1st case Female 18Y H:168cm,W:54Kg(1994)
Acne symptoms were painfull located in Isotretinoin: was originally
the chin,cheeks, chest,back
recommended for people with severe acne that did not respond to other The skin condition affected her self- treatments 'nuclear option' for acne
confidence, felt shy Exactly how Accutane works on a cellular 19-20 Y old(1995-96), Prescribed: Minocin level is unknown but we do know that it
(tetracycline) for 2 months, Vibramycin
affects all four ways that acne develops. 1. It dramatically reduces the size of the Accutane 10mg ( isotretinoin) for 4
skin's oil glands (35%-58%) and even
months1997-21Y old more dramatically reduces the amount of oil these glands produce (around 80%).8-9 Post treatment 1997 changes took place:
2. Acne bacteria (P. acnes) live in skin oil.
Was happy after treatment since skin Since oil is dramatically reduced, so is the condition was overall improved. amount of acne bacteria in the skin.9 Very irritable,screaming,fighting 3. It slows down how fast the skin Dry lips & burning sensation
produces skin cells inside the pore, which
helps pores from becoming clogged in the Dry skin & itching
Knee pain (L)
4. It has anti-inflammatory properties.10
Side effects 1st case
Isotretinoin More common:
Bone or joint pain+++
changes in behavior+
mental depression ++
aggression or agitation.
difficulty moving+

dryness of the lips+
cracking or peeling skin
tiredness, weakness+
This is not a complete list of the side effects.

Remark: Isotretinoin action on a cellular level
is unknown
epigenic impact is of concern13
2Y later. Knee pain accompanied with acne1999
3rd Homeopathic Doctor2009-2014 1st Homeopathic Doctor:1999-2008 33Y Tarentula 10M Skin reaction2009 Acne facial resolved 34Y2010 Calc-c,Bry,Coloc,China,Gels,Hep,Ip,Kali-bi, Recurent Vaginal Candidiasis since 2010
Nux-v,Puls,Sep,Rhus-t, Sulp,Calc-c, Phos,
Itching 2013. R: Antifungal treatment per Os for candidiasis, Phos main Homeop Remedy 23-28Y Acne reappeared under intense Severe Left Hip pain2012 (she linkes with candidiasis)
2nd Homeopathic Doctor:2008-2010 R: conventional medication and painkillers.Hip joint replacement 5-08 Calc-c 200ch,1M Anxiety-weakness
7-2013 Phosp 1M/3 Anxiety, 12-08 Natr-m 200ch,1M Herpes,Acne 10-13 Phos 1M, 11-13 Phos 10M, 31-12-08 Sulp 30ch/4 Acute skin rashes 01-09 Arnica 200/3 back-injury (+nimesulid) 1-14 Ign 1M (reaction-pict.)
3-14 Ars.
3-2010 Ars30ch/4 (Ign?) GIT&Anxiety 1st case evaluation Acne is no more present • High creativity • Mild-moderate scaring • Muscle-skeletal recurrent complains (algias) • Sensitive to stress • Grief-conflicts • Anxiety & fears Palliative Homeopathic treatment 2nd case: Male 16Y, 172cm W:62kg (1984) • Treated for conjunctivitis 4-7-1984 with Maxitrol (neomycin and polymyxin B
sulfates and dexamethasone) • Acne onset • 9-8-1984 administered tetracyclines and locally with Fenistil (Dimetindene maleate) & Retavate cream (Adrenal cortical steroids, Glucocorticoids) • 9-1984 Treatment was non rewarding the efforts thus switched to Homeopathy and complementary dermatology. Homeopathy + nutrition
Nutrition was modified banning most beverages and sugar.
• The skin condition included large staphylococcus papules in the face accompanied
with itching and soreness • The homeopathic treatment for Acne supported the nutritional modification and the remedy fitted both constitutional and local symptomatology.
• The skin pathology cleared with the first prescription and and non-scaring
• Homeopathy was chosen as main course of treatment until today.2014 Side effects (drugs.com) 2nd case Neomycin-(less serious):
mild nausea, vomiting
severe headache, dizziness, blurred vision;
mild diarrhea.
fever, chills, body aches, flu symptoms;
polymyxin B Incidence not known Dizziness
severe blistering, peeling, and red skin rash; Drowsiness, fever, headache, stiff neck
urinating less than usual or not at all; numbness or tingling in hands or feet, pain in pale or yellowed skin, dark colored urine, fever, confusion the lower back or side, shakiness and unsteady or weakness
walk, unsteadiness, trembling, or other severe pain in your upper stomach spreading to your back, problems with muscle control or coordination nausea and vomiting, fast heart rate;
More common loss of appetite, jaundice (yellowing of the skin or eyes); or
easy bruising or bleeding, unusual weakness. Aggression, agitation, anxiety, blurred vision Less serious tetracycline side effects may include: decrease in the amount of urine sores or swelling in your rectal or genital area; Dizziness- headache-mood changes
mild nausea, vomiting, diarrhea, or stomach upset; Irritability, mental depression, Nervousness, fast, slow, pounding, or irregular heartbeat or white patches or sores inside your mouth or on your lips; swollen tongue, trouble swallowing; or noisy, rattling breathing,numbness or tingling in • vaginal itching or discharge. the arms or legs,pounding in the ears, shortness • This is not a complete list of side effects and others may
of breath, swelling of the fingers, hands, feet, or occur….
lower legs, trouble thinking, speaking, or walking, troubled breathing at rest,weight gain Incidence not known: • Patient declares that he was feeling very ugly, being rude, acne was partially relieved bathing in the sea.
Post treatment (1984-1986)changes took place:
became better student
less desire for sugar
No- scar more social, self-confidence
began to train
acquired a more positive & creative attitude in life since.
Treatment details • 1st Homeopathic Doctor 12-1984 Sulph 1M, 12ch/30caps (Acne) ↑↑
05-1986 >> 12ch/10 nose obstruction 02-1987 >> 200ch, 12ch/30 01-1992 >> 12ch/30 02-1993 Gels 200ch,6x/10 - Ign200ch Ancient scholars have uncovered evidence of sulfur and mineral water
10-1993 Puls 200ch,6x/30 treatments in ancient Rome . 03-1994 Nat-M 200ch,1M,6x/30 As far as historians can tell, sulfur, despite its questionable 07-1994 Arn 200ch, 12ch/10 efficacy, was the most popular acne
treatment used in antiquity, all the
06-1995 Puls 200ch,50M (sore
way up until the 20th century when a abdomen&sadness) ↑↑
bevy of other treatments started to 07-2003 Sulphur 200ch,1M,6x/30 • 3-2005 Sulphur 1M weakness 02-2009 ARS 200ch • 9-2005 >> 1M,10M 03-2009 Sang 30ch • 2005 Merc-s 200ch apthae ulcers 03-2009 Bell 200ch,1M 03-2009 Staph 1M Migrains & GIT-disorders (multi-
04-2009 Nux-V 200ch ………Puls, Nat-m, Ver-A, Ign, Phos.2011 • 10-2005 ARS 200ch 9-2012 Arg-N 200ch,1M • 9-2006 >> Nausea, Vomiting, Diarrhea
12-2012 Ign 200ch • 10-2006 Sulph 200ch,1M,10M • 10-2006 Phos 200ch GIT+Anxiety
3-2013 Bry 200ch,1M cough suffocative
12-2006 ARS 1Mx4 2-2014 Lyc 1M pain temples on cough-
• 8-2007 ARS 200ch • 6-2008 Sang 200ch,1M 1-4-2014 >> 10M (coffe) • 9-2008 Ars 200ch 18-6-2014 Sulp 200,1M tooth pain&back
• 1-2009 Sang 200ch,30ch Evaluation 2nd case • No tissue scaring • Achieved Emotional- mental-physical Homeostasis - Impulsiveness - Bone fractures Top Homeopathic Remedies for Acne
The' magic medicine' in homeopathy that helped me clear of my acne was Sulphur !
Pulsatilla: Young Girls Suffering from Acne with menstrual difficulties
Hepar sulpur: cases of acne, pustular in nature& white heads with pus points.
-Arnica Montana. With marked facial bruises
-Antimonium Tartaricum- brunish scars
-Sulphur iodatum- Acne in forehead and back
Natrium muriaticum
-Lycopodium: skin rushes & Git disordres
-Nux Vomica- uses stimulants and medication
-Pulsatilla- bluish color on rushes
Kalium bromatum .
-Sepia- irritability
-Psorinum- eldery
-Hepar sulphur -acne rushes sensitive to touch.
-Calcarea Sulphurica-short periods of acne.
-Calcarea Phosphorica-weakness in youths
Face –eruption- mouth around 1-2014 male 12Y ( initially suppressed with
cortisteroids for 6 months) • Kent: Ant-t, Ars, Graph, Kali-chl, Kreo, Nat-ar,
Nat-c, Nat-m, Nit-ac,
Rhus-t, Sep, Staph, Sulp.
R :Puls 1M/10M Result: in two days clear Individualization! Homeopathy friendly local treatments substance
Side effects
sebum from

Inhibit bacterial Collagen synthesis Dryness observed
Collagen synthesis Increase Dermal Perfusion Exfoliates,penetrates Green for oily and
Acneic skins, White
:children and
sensitive skins
Appropriate responsiveness of the human Acne vulgaris appears mostly in adolescence, stress system to stressors is a crucial due to the fact that the primary change in that prerequisite for a sense of wellbeing, age is hormonal outbreak and onset of human adequate performance of tasks, and interrelationships. positive social interactions, and hence for Conventional medication Load (complexity
the survival of the self and the species. By intensity & duration) will have an epigenic effect
contrast, inappropriate, over or under - responsiveness of the stress system may Any treatment or suppression will affect the impair growth and development, and may health homeostasis in a long term base . account for the many chronic behavioral, Such a suppression limits an individual well endocrine, metabolic, and autoimmune being and happiness. disorders that plague contemporary humanity. Prenatal life, infancy, childhood
Acne can be resolved both with conventional or and adolescence are critical periods
complementary medicine characterized by great plasticity and Classical homeopathy provides permanent cure increased vulnerability to stressors, in
with no scaring or relapse. which homeostatic mediators exert
major organizational epigenetic effects.
The genetic vulnerabilities leading to
contemporary chronic diseases resulted
from selective pressures of evolutionary
stressors upon the genome during human
This survey points out that there is delayed response to common medication
for acne. In three years time for the first case, there was a relapse in
pathology that was followed with left lower joint pain. Second case had
migrains & GIT-disorders 20 years later. Epigenetic science that refers to a
change in the expression of a gene, rather than in the actual base
combinations (Dworkin, 2009) . Drugs may alter epigenetic homeostasis by
direct or indirect13&1st case mechanisms. It becomes increasingly apparent that
chemicals(common pharmaceuticals) can cause changes in gene expression
that persist long after exposure has ceased.12 There is a need for further
investigation to understand the mechanisms. Homeopathy has shown its
efficiency treating acne especially in puberty ,conventional medication has to
be used for treatment with acne with skepticism.
1 ARISTOTLE. Historia Animalium, 556b, 29; Problemata, 36, 3; in Ed. Casaubon (1605) pp. 654B, 639E. 2 HIPPOCRATES. De Morbis Vulgaribus; in Loeb Classical Library, Hippocrates, 1, 188. De Internus Affectionibus; in Ed. Kuhn (1826) Medicorum Grecorum Opera, 22, 427. 3 PLINY. Historia Naturalis, Lib. 23; in Ed. Mayhoff, Lipsiae (1897) 4, pp. 7, 8, 27, 28. 4 CELSUS. De Medicina, Lib. 6, Cap. 5; Lugduni (1592) p. 552; Lee, London (1831) p. 136. 5. BUDGE, E. A. W. (1920) An Egyptian Hieroglyphic Dictionary. London; p. 11. 6.EBERS PAPYRUS. Tafel 71, line 21 and glossary; Engleman, Leipzig (1875). 7. Effects of science and technology on nature and environment: Genes, Brain, Stress and Evolution GP Chrousos(Ann Clin Paediatr 2009, 56(4):555-558) 8. Am Fam Physician. 2001 Dec 1;64(11):1873-8. Psycho dermatology: the mind and skin connection.Koo J1, Lebwohl A. 9.Aegean Univ Msc paper in Hoklistic approach Psycho dermatology (Ολιστική προσέγγιση της Ψυχοδερματολογίας με Κλασσικά, Ψυχοδυναμικά και Εναλλακτικά Μοντέλα). Anastasios Tsilikas MD 10. P. Papageorgiou, A. Katsambas, A. Chu (2000) Phototherapy with blue (415 nm) and red (660 nm) light in the treatment of acne vulgaris British Journal of Dermatology 142 (5), 973–978. 11. Antibacterial properties of propolis . J M Grange and R W Davey. J R Soc Med. Mar 1990; 83(3): 159–160. 12. Epigenetic side-effects of common pharmaceuticals: a potential new field in medicine and pharmacology. Csoka AB1, Szyf M. 2009 Nov;73(5):770-80. 2008.10.039. Epub 2009 Jun 5. 13. Temporal changes in gene expression in the skin of patients treated with isotretinoin provide insight into its mechanism of action. Amanda M Nelson, Wei Zhao,† Kathryn L Gilliland, Andrea L Zaenglein, Wenlei Liu,‡ and Diane M Thiboutot. Dermatoendocrinol. 2009 May-Jun; 1(3): 177–187. www.mihalakis.eu

Source: http://www.homeodentistry.gr/Case%20reports%20of%20Acne.pdf


Ital J Gastroenterol l993; 25:174-178 ORIGINAL ARTICLES A randomized controlled trial of a new PEG-electrolyte solutioncompared with a standard preparation for colonoscopy OA PAOLUZI, MARIA CARLA DI PAOLO, F RICCI, C PASQUALI, S ZARUG, F DE LIBERO, P PAOLUZICattedra di Gastroenterologia, Istituto di Il Clinica Medica, Università "La Sapienza", Roma, Italy